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首页> 外文会议>First global congress on nanoengineering for medicine and biology 2010 >RHO-GTPase REGULATION BY GEFs, GAPs AND GDIs IN CELL MIGRATION
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RHO-GTPase REGULATION BY GEFs, GAPs AND GDIs IN CELL MIGRATION

机译：GEF，GAP和GDI在细胞迁移中对RHO-GTPase的调节

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The family of small RhoGTPases plays a crucial role in the spatial and temporal coordination cell migration. GEFs, GAPs and GDIs are the enzymes that regulate their activity, although the mechanism is poorly understood. Regulation models proposed to date have focused on GEFs as the main modulators of RhoGTPase activity, leaving a passive role to GAPs and GDIs. In this work we show that this assumption leads to models with properties that may be inconsistent with observations, more precisely, appearance of Turing instabilities and reduced sensitivity to secondary stimuli. The mathematical basis of this behavior is established, and a general class of interaction schemes that bypass it by including GAP and GDI regulation, which is supported by experimental evidence, is proposed.
机译：小RhoGTP酶家族在空间和时间协调细胞迁移中起关键作用。 GEF，GAP和GDI是调节其活性的酶，尽管对其机理了解甚少。迄今为止，提出的监管模型已将GEF作为RhoGTPase活性的主要调节剂，而对GAP和GDI则保持被动作用。在这项工作中，我们证明了这种假设导致模型的性质可能与观察结果不一致，更确切地说，是图灵不稳定性的出现和对次级刺激的敏感性降低。建立了此行为的数学基础，并提出了通过包括GAP和GDI调节来绕过该行为的通用交互方案类，并得到了实验证据的支持。

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