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首页> 外文会议>Laser Florence 2017: Advances in Laser Medicine >EVALUATION OF PHOTOTHERAPY IN THE DIFFERENTIATION OF MESENCHYMAL STEM CELLS IN THE TISSUE REPAIR OF RATS SUBMITTED TO A HYPERLIPIDEMIC DIET
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EVALUATION OF PHOTOTHERAPY IN THE DIFFERENTIATION OF MESENCHYMAL STEM CELLS IN THE TISSUE REPAIR OF RATS SUBMITTED TO A HYPERLIPIDEMIC DIET

机译：高脂饮食大鼠组织修复中间充质干细胞分化的光疗评价

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摘要

Obese people present a greater risk of developing other systemic diseases and comorbidities such as compromising the tissue repair process. Laser phototherapy can contribute to this repair by improving cellular functions, since stem cells may play an important role in repair due to their pluripotent potential. In this way, the influence of Laser Phototherapy (LP) was evaluated in the tissue repair of rats submitted to a hyperlipid diet through CD49 immunostaining for adipose stem cells. Forty-eight Wistar albinus rats were divided into two experimental groups: Standard Diet (SD) and Hyperlipid Diet (HD) for 20 weeks. After this period, excisional dorsal cutaneous wounds of 1 cm2 were made. The groups were subdivided into control and laser, the laser groups were irradiated (Diode Laser of Gallium and Aluminum Arsenide, λ660nm, 40mW, 6J / cm2) immediately after the surgery and every 48 hours. A group of rats were killed on day 7 and the other group on day 14 and the specimens processed by the immunohistochemical technique. The SD group presented antibodies marked with moderate to intense intensity, whereas in the HD group the weak staining for the time of 14 days prevailed. The irradiation protocol employed had no influence on the CD49 marker when compared to the control and irradiated groups over the same period. According to the methodology used and the results obtained it is concluded that laser light does not influence the recruitment of adipoderivative stem cells for the tissue repair process.
机译：肥胖的人呈现出其他全身性疾病和合并症的更大风险，例如损害组织修复过程。激光光疗可以通过改善细胞功能来促进这种修复，因为干细胞由于其多潜能而在修复中起着重要作用。通过这种方式，通过对脂肪干细胞进行CD49免疫染色，在接受高脂饮食的大鼠的组织修复中评估了激光光疗（LP）的影响。将48只Wistar albinus大鼠分为两个实验组：标准饮食（SD）和高脂饮食（HD），持续20周。在此期间之后，进行了1 cm2的切除性背侧皮肤伤口。将各组分为对照组和激光组，在手术后立即每48小时照射一次激光组（镓和砷化铝的二极管激光器，λ660nm，40mW，6J / cm2）。一组大鼠在第7天被处死，另一组在第14天被处死，并且通过免疫组织化学技术处理样品。 SD组呈递的抗体具有中等至强烈的强度，而HD组呈14天的弱染色。与同一时期的对照组和受辐照组相比，所采用的辐照方案对CD49标记没有影响。根据所使用的方法和获得的结果，可以得出结论，激光不影响脂肪变性干细胞在组织修复过程中的募集。

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  • 来源
    《Laser Florence 2017: Advances in Laser Medicine》|2017年|105820A.1-105820A.12|共12页
  • 会议地点 Florence(IT)
  • 作者

    CRB Oliveira; LS Santos; VDU Silva; LA Vitoria; TT Rodriguez; AMC Marques; FCA Xavier; L Ramalho;

  • 作者单位

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

    School of Medicine, Bahia Foundation for the Development of Sciences, Salvador, Brazil;

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

    School of Medicine, Bahia Foundation for the Development of Sciences, Salvador, Brazil;

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

    School of Dentistry, Federal University of Bahia, Salvador, Brazil;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    tissue repair; lasertherapy; stem cells; immunohistochemistry;

    机译：组织修复；激光疗法干细胞;免疫组化;

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