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Form Follows Function Model-Driven Engineering for Clinical Trials

机译：表格遵循功能模型驱动的工程进行临床试验

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摘要

We argue that, for certain constrained domains, elaborate model transformation technologies-implemented from scratch in general-purpose programming languages-are unnecessary for model-driven engineering; instead, lightweight configuration of commercial off-the-shelf productivity tools suffices. In particular, in the CancerGrid project, we have been developing model-driven techniques for the generation of software tools to support clinical trials. A domain metamodel captures the community's best practice in trial design. A scientist authors a trial protocol, modelling their trial by instantiating the metamodel; customized software artifacts to support trial execution are generated automatically from the scientist's model. The metamodel is expressed as an XML Schema, in such a way that it can be instantiated by completing a form to generate a conformant XML document. The same process works at a second level for trial execution: among the artifacts generated from the protocol are models of the data to be collected, and the clinician conducting the trial instantiates such models in reporting observations-again by completing a form to create a conformant XML document, representing the data gathered during that observation. Simple standard form management tools are all that is needed. Our approach is applicable to a wide variety of information-modelling domains: not just clinical trials, but also electronic public sector computing, customer relationship management, document workflow, and so on.
机译：我们认为，对于某些受约束的领域，用模型编程的工程从头开始实施的复杂模型转换技术是不必要的；取而代之的是，商用现成的生产力工具的轻量级配置就足够了。特别是在CancerGrid项目中，我们一直在开发模型驱动的技术，以生成支持临床试验的软件工具。域元模型捕获了社区在试验设计中的最佳实践。一位科学家编写了一个试验方案，通过实例化元模型对试验进行建模。从科学家的模型自动生成支持试验执行的定制软件工件。元模型表示为XML模式，可以通过完成表单以生成一致的XML文档来实例化元模型。相同的过程在第二级用于试验执行：从协议生成的工件中包括要收集的数据的模型，进行试验的临床医生再次通过填写表格以创建符合标准的模型来实例化此类模型以报告观察结果。 XML文档，表示在该观察期间收集的数据。仅需要简单的标准表单管理工具。我们的方法适用于各种信息建模领域：不仅是临床试验，还包括电子公共部门计算，客户关系管理，文档工作流程等。

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  • 会议地点 Johannesburg(ZA)
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    Jim Davies; Jeremy Gibbons; Radu Calinescu; Charles Crichton; Steve Harris; Andrew Tsui;

  • 作者单位

    Department of Computer Science, University of Oxford,Wolfson Building, Parks Road, Oxford 0X1 3QD, UK;

    Department of Computer Science, University of Oxford,Wolfson Building, Parks Road, Oxford 0X1 3QD, UK;

    Computer Science Research Group, Aston University,Aston Triangle, Birmingham B4 7ET, UK;

    Department of Computer Science, University of Oxford,Wolfson Building, Parks Road, Oxford 0X1 3QD, UK;

    Department of Computer Science, University of Oxford,Wolfson Building, Parks Road, Oxford 0X1 3QD, UK;

    Department of Computer Science, University of Oxford,Wolfson Building, Parks Road, Oxford 0X1 3QD, UK;

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