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首页> 外文会议>Frontier of nanoscience and technology >Combination of Microemulsion for Topical Deliverying tripterygium wilfordii multiglycoside
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Combination of Microemulsion for Topical Deliverying tripterygium wilfordii multiglycoside

机译：雷公藤多甙局部给药的微乳剂组合

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The purpose of this study was to explore the potential application of the combination of microemulsion as a topical delivery vehicle in enhancing the absorption and efficacy of tripterygium wilfordii multiglycoside (TWM). Various microemulsion formulations were developed and an optimal microemulsion (TWM-ME), which presented spherical droplets and consisted of RH-40, IPM and water was 27: 3.3: 69.7 by weight. It possessd an average droplet size of 23.6 nm, a low viscosity of (3.56±0.12) mm2s-l Zeta electric potential was (-5.35±0.42) mV, refractive index was (1.3617±0.0051) nD20, conductivity was (97.6±3.6) μs/cm. Compared to the control solution, TWM-ME provided better skin permeability in vitro. Moreover, TWM-ME has noticeable anti-inflammatory and immune suppression effect. These results indicate that the combination of microemulsion represents an effective vehicle for topical delivery of TWM.
机译：这项研究的目的是探讨微乳剂组合作为局部给药载体在增强雷公藤多甙（TWM）的吸收和功效方面的潜在应用。开发了各种微乳剂配方，最优的微乳剂（TWM-ME）呈球形液滴，由RH-40，IPM和水组成，重量比为27：3.3：69.7。它的平均液滴尺寸为23.6 nm，低粘度（3.56±0.12）mm2s-l Zeta电位为（-5.35±0.42）mV，折射率为（1.3617±0.0051）nD20，电导率为（97.6±3.6） ）μs/ cm。与对照溶液相比，TWM-ME在体外具有更好的皮肤渗透性。此外，TWM-ME具有明显的抗炎和免疫抑制作用。这些结果表明，微乳液的组合代表了局部递送TWM的有效载体。

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