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首页> 外文会议>Frontiers in biological detection: from nanosensors to systems VI >An imaging magnetometer for bio-sensing based on nitrogen-vacancy centers in diamond
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An imaging magnetometer for bio-sensing based on nitrogen-vacancy centers in diamond

机译：基于金刚石中氮空位中心的生物传感成像磁力计

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摘要

We present a widefield microscopy system for imaging super-paramagnetic nanoparticles (SPNs), and propose to use it as a bio-sensing system wherein SPNs are used as tags. Potential advantages of magnetic tags over conventional fluorescent tags include the elimination of noise from auto-fluorescence, optical isolation of the biological system from the measurement apparatus, and the potential for magnetic removal of non-specifically bound material. The microscope magnetic sensing surface is composed of a thin layer of nitrogen-vacancy defect centers in the top 200 nm of a diamond substrate. Nitrogen-vacancy centers in diamond have been shown to be suitable for use as highly sensitive magnetometers due to their long spin-coherence time at room temperature. Furthermore, spin-dependent photoluminescence allows for simple far-field optical readout of the spin state, which in turn allows for optically-detected magnetic resonance measurements. We will present our results detecting a single, lithographically defined 50 nm diameter by 100 nm thick iron nanodot. With the current sensitivity of 9 μT·Hz~(-1/2), we expect to be able to detect single 20 nm magnetite SPNs, our proposed tags, in less than one minute. By further optimizing the sensor surface, we predict DC magnetic sensitivities as low as 1 μT·Hz~(-1/2).
机译：我们提出了一种用于成像超顺磁性纳米粒子（SPNs）的宽视场显微镜系统，并建议将其用作生物传感系统，其中SPN用作标签。磁性标签相对于常规荧光标签的潜在优势包括：消除自发荧光产生的噪声，将生物系统与测量设备进行光学隔离以及磁性去除非特异性结合材料的潜力。显微镜磁感测表面由位于金刚石基板顶部200 nm的薄层氮空位缺陷中心组成。金刚石中的氮空位中心因在室温下自旋相干时间长而被证明适合用作高灵敏磁力计。此外，自旋相关的光致发光允许对自旋状态进行简单的远场光学读出，从而允许进行光学检测的磁共振测量。我们将介绍检测单个光刻定义的直径为50 nm直径乘以100 nm厚的铁纳米点的结果。我们希望在9μT·Hz〜（-1/2）的电流灵敏度下，在一分钟内就能检测出我们提出的标签20 nm磁铁矿SPN。通过进一步优化传感器表面，我们预测直流磁灵敏度可低至1μT·Hz〜（-1/2）。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Michael Gould; Russell Barbour; Chris Chen; Zhiting Zhu; Kai-Mei Fu;

  • 作者单位

    Dept. of Electrical Engineering, Univ. of Washington, 185 Stevens Way, Seattle, WA, USA 98195-2500;

    Dept. of Electrical Engineering, Univ. of Washington, 185 Stevens Way, Seattle, WA, USA 98195-2500;

    Dept. Computer Science and Engineering, Univ. of Washington, 185 Stevens Way, Seattle, WA, USA 98195-2350;

    Dept. Computer Science and Engineering, Univ. of Washington, 185 Stevens Way, Seattle, WA, USA 98195-2350;

    Dept. of Electrical Engineering, Univ. of Washington, 185 Stevens Way, Seattle, WA, USA 98195-2500,Dept. of Physics, Univ. of Washington, 3910 15th Ave. NE, Seattle, WA, USA 98195-1560;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Nitrogen-vacancy center; magnetometry; superparamagnetic nanoparticles; bio-sensing;

    机译：氮气空缺中心；磁力计超顺磁性纳米粒子生物传感;

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