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首页> 外文会议>Optics in health care and biomedical optics VIII >Comparative Study between Diagnostic Mediums: Human Tissue and Saliva for Oral Cancer Detection using Stokes Shift Spectroscopy
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Comparative Study between Diagnostic Mediums: Human Tissue and Saliva for Oral Cancer Detection using Stokes Shift Spectroscopy

机译：诊断介质：人体组织和唾液用于斯托克斯频移光谱法检测口腔癌的比较研究

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摘要

A comparative study has been accomplished between diagnostic mediums: human oral tissue and saliva for oral cancer detection on three groups: oral squamous cell carcinoma (OSCC), dysplastic, and control (normal) by using Stokes shift (SS) spectroscopy (SSS) at Δλ of 120 nm, which is the Stokes shift of nicotinamide adenine dinucleotide (NADH). SS spectra obtained from tissue and saliva consist of major bands of collagen, tryptophan, NADH and minor bands of flavin adenine dinucleotide (FAD) and porphyrin. Principal component analysis (PCA) has been performed on the data sets of SS spectra for discrimination by dimension reduction. Linear discriminant analysis (LDA) has been applied on the PC scores to compute linear discriminant (LD) scores. Kernel probability density functions of LD scores are plotted to show how LD scores of each group are separated from one another. LD scores for oral tissue differentiates OSCC to normal, dysplasia to normal, and OSCC to dysplasia with sensitivities 100 %, 85 %, 94 % and specificities 88 %, 88 %, 89 % with the accuracy of 95 %, 87 % and 92 %. On the other hand for saliva, it differentiates respective groups with sensitivities 91 %, 82 %, 91 % and specificities 100 %, 88 %, 82 % with the accuracy of 95 %, 85 % and 87 %. Obtained results with human saliva are as prominent as oral tissue and we conclude that it may be used as a substitute diagnostic medium. In addition SS spectroscopy instead of fluorescence spectroscopy at 120 nm shift appears to be an important tool for in vivo detection of early oral cancer.
机译：通过使用斯托克斯频移（SS）光谱仪（SSS）在以下三种诊断介质之间进行了比较研究：诊断人类口腔组织和唾液，用于三组口腔癌检测：口腔鳞状细胞癌（OSCC），增生异常和对照（正常）。 120 nm的Δλ，即烟酰胺腺嘌呤二核苷酸（NADH）的斯托克斯位移。从组织和唾液获得的SS光谱由胶原蛋白，色氨酸，NADH的主要谱带以及黄素腺嘌呤二核苷酸（FAD）和卟啉的次要谱带组成。已对SS光谱数据集进行了主成分分析（PCA），以通过降维进行区分。线性判别分析（LDA）已应用于PC分数，以计算线性判别（LD）分数。绘制LD分数的内核概率密度函数，以显示每一组的LD分数如何彼此分离。口腔组织的LD评分可将OSCC与正常，发育异常与正常以及OSCC与发育异常区分开来，敏感性为100％，85％，94％，特异性为88％，88％，89％，准确度为95％，87％和92％ 。另一方面，对于唾液，它区分敏感性为91％，82％，91％和特异性100％，88％，82％的各个组，准确度为95％，85％和87％。人类唾液获得的结果与口腔组织一样显着，我们得出的结论是它可以用作替代诊断介质。此外，SS光谱代替120 nm位移的荧光光谱似乎是体内检测早期口腔癌的重要工具。

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