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首页> 外文学位 >Tissue-on-tissue lubricity studies of saliva substitutes as-supplied, mixed with and compared with human saliva from control and xerostomia patients.
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Tissue-on-tissue lubricity studies of saliva substitutes as-supplied, mixed with and compared with human saliva from control and xerostomia patients.

机译：对照和口腔干燥症患者唾液替代品的组织，组织润滑性研究。

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摘要

Relief is sought from "dry mouth" symptoms in increasingly older populations experiencing side effects from xerostomic drugs, multi-drug interactions, and cancer therapies. This investigation applied a new tissue-on-tissue lubricity test procedure, which has shown clinical correlations leading to successful formulations for relieving "dry eye" symptoms, to commercial saliva substitutes as-formulated and after admixture with pre-applied aliquots of unstimulated saliva from ten normal control vs ten xerostomia patients in a protocol approved by a Human Subjects Institutional Review Board. From 31 identified commercial products, 19 were available for laboratory testing of their intrinsic capabilities to reduce Coefficients of Friction (CoF) of saline-wetted articulating pericardium couples, sustain those CoF reductions over time, and demonstrate substantivity of the friction-reduction effects after further dilution by physiologic buffer, as related to their pH values, surface tensions, and functional ingredients characterized by Multiple Attenuated Internal Reflection InfraRed (MAIR-IR) spectroscopy. The most effective constituents were rinse-resistant natural polysaccharides such as linseed extracts and xanthan gum, at neutral pH, while formulations at both low and high pH or based on synthetic carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, as well as natural esters and glycerin, were generally not lubricious or were less substantive (except for undisclosed silicone components in some products). Intrinsic lubricities of saliva from both patient groups were excellent, reducing CoF values from above 0.4 to about 0.1 in all cases, and saliva aliquots sustained these CoF reductions after additions of 4 different saliva substitutes selected to examine their admixture effects on continuing lubricity and substantivity.;It was demonstrated that small amounts of natural saliva can convey their superior lubricity to saliva substitutes not very lubricious alone. Based on these results and comparative MAIR-IR spectra showing similar carbohydrate-to-protein ratios, in spite of lower pH values for xerostomia saliva specimens, xerostomic saliva was proven to be deficient mainly in amount secreted, and not in composition or function as a superior tissue lubricant. Unstimulated saliva from daily samples of a pre-menopausal female control subject did show pH and MAIR-IR spectral variations suggesting a possible confounding effect of cyclic hormonal influences on these lubricious secretions. Studies with experimental formulations showed results superior to those of natural saliva and all saliva substitutes tested, providing guidance for further efforts aimed at producing xerostomia-relief formulations of sufficient potency and substantivity to be safely and effectively delivered by intra-oral prosthetic devices.
机译：寻求缓解的方法是在越来越多的老年人口中出现“口干”症状，这些患者正遭受来自干口性药物，多种药物相互作用和癌症治疗的副作用。这项研究应用了新的组织对组织润滑性测试程序，该程序已显示出与临床配方相关的成功配方，这些配方可成功缓解配方中的商业唾液替代物并与预先应用的未刺激唾液等份混合后缓解“干眼症”症状。在人类受试者机构审查委员会批准的方案中，十名正常对照vs十名口腔干燥症患者。从31种已确定的商业产品中，有19种可用于实验室测试其内在能力，以降低盐水润湿的铰接心包对的摩擦系数（CoF），随着时间的推移维持这些CoF的降低，并证明进一步降低摩擦效果的实质性由生理缓冲液稀释的溶液，与它们的pH值，表面张力和功能成分有关，这些成分以多重衰减内部反射红外（MAIR-IR）光谱为特征。最有效的成分是在中性pH下耐漂洗的天然多糖，如亚麻籽提取物和黄原胶，而在低pH和高pH下或基于合成羧甲基纤维素，羟乙基纤维素，羟丙基纤维素以及天然酯和甘油的制剂通常是不润滑或实质性较差（某些产品中未公开的有机硅成分除外）。两组患者唾液的固有润滑性均极佳，所有情况下的CoF值均从0.4降低至约0.1，并且在添加4种不同的唾液替代品以检查其混合物对持续润滑性和直接性的混合作用后，唾液等分试样维持了这些CoF降低。 ；事实证明，少量的天然唾液可以将其优越的润滑性传递给不是很润滑的唾液替代品。根据这些结果和比较的MAIR-IR光谱显示出相似的碳水化合物与蛋白质的比率，尽管口干唾液标本的pH值较低，但经证明口干唾液主要缺乏分泌量，没有组成或功能。上等组织润滑剂。绝经前女性对照者日常样品中未刺激的唾液确实显示出pH和MAIR-IR光谱变化，表明循环激素对这些润滑分泌物可能产生混杂影响。对实验配方的研究表明，结果优于天然唾液和所有测试的唾液替代品，为进一步努力提供了指导，旨在生产具有足够效力和实质性的口干口气配方，以通过口腔内修复设备安全有效地递送。

著录项

  • 作者

    Ganesh, Rashmi.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Health Sciences Dentistry.;Engineering Materials Science.
  • 学位 M.S.
  • 年度 2010
  • 页码 239 p.
  • 总页数 239
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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