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首页> 外文会议>IEEE Annual Northeast Bioengineering Conference >Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects
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Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects

机译：在OSAS和对照对象中使用体积门控MRI在潮气呼吸期间上呼吸道的计算流体动力学建模

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Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and -124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.
机译：对于阻塞性睡眠呼吸暂停患儿，尚未进行潮气呼吸过程中气道变形的三维（3D）分析。我们使用体积门控磁共振图像对一名阻塞性睡眠呼吸暂停综合症（OSAS）和一名对照的儿童的气道进行分割，表面和体积划分。在每个气道上以对应于呼吸周期10个时间点的流速对每个气道进行了计算流体动力学（CFD）研究，该流速是从12个连续呼吸周期的平均流量数据中提取的。 3D CFD分析显示，OSAS受试者的最小吸气压力为-250.76 Pa，对照组为-124.24 Pa。门控MRI图像描绘了OSAS受试者在整个吸气周期中气道容积总体减少了47％，而对照组则没有崩溃。校正了鼻阻力和湍流动能数据的压力分布表明，OSAS中的气道可折叠性是咽阻力和流体及组织力学的函数，而不是整个鼻阻力。

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