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首页> 外文会议>IEEE Uttar Pradesh Section International Conference on Electrical, Electronics and Computer Engineering >Conducting artificial enzymatic nanocubes based electronic sensor for simultaneous detection of hemoglobin and glycated hemoglobin in diabetic patients
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Conducting artificial enzymatic nanocubes based electronic sensor for simultaneous detection of hemoglobin and glycated hemoglobin in diabetic patients

机译：进行基于人工酶纳米立方体的电子传感器，以同时检测糖尿病患者的血红蛋白和糖化血红蛋白

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摘要

Artificial enzymes are man-made enzymes which mimics the natural enzymes and can be use in various biomedical applications. In this paper, nanocubes shape conducting artificial enzymes modified flexible electrochemical sensor was fabricated for simultaneous sensing of glycated hemoglobin and hemoglobin where percentage of glycated hemoglobin is proven gold biomarker for diabetes. The simultaneous electrochemical sensing of hemoglobin and glycated hemoglobin is achieved using conducting artificial enzymatic nanocube based flexible carbon paste aluminium foil. Here, conducting artificial enzymatic nanocubes are prepared by molecular imprinting technology which promoted the fast kinetics of redox process and low detection limit of both hemoglobin and glycated hemoglobin with linear response of concentrations. The characteristic well define symmetrical separate peaks for both hemoglobin and glycated hemoglobin was obtained in aqueous and human blood samples. This novel cheap flexible sensor with remarkable dual selectivity and sensitivity could be used to determine hemoglobin and glycated hemoglobin at ultra-trace level in diabetic patient blood sample with 0.07 μM and 0.09 μM detection limit. Thus proposed flexible sensor can be a smart wearable sensor for diabetic monitoring.
机译：人造酶是模仿天然酶的人造酶，可用于各种生物医学应用。在本文中，制造了纳米立方体形状传导人工酶修饰的柔性电化学传感器，用于同时感测糖化血红蛋白和血红蛋白，其中糖化血红蛋白的百分比被证明是糖尿病的黄金生物标志物。血红蛋白和糖化血红蛋白的同时电化学感应是通过使用基于人工酶纳米立方体的柔性碳糊铝箔实现的。在这里，通过分子印迹技术制备了可传导氧化酶过程的快速动力学方法，从而降低了血红蛋白和糖化血红蛋白的检出限，并具有浓度线性响应的特性，从而制备了人工酶纳米立方体。该特征很好地定义了在水性和人血样品中获得的血红蛋白和糖化血红蛋白的对称分离峰。这种新颖的廉价柔性传感器具有出色的双重选择性和灵敏度，可用于以0.07μM和0.09μM的检出限检测超微量水平的糖尿病患者血样中的血红蛋白和糖化血红蛋白。因此，提出的柔性传感器可以是用于糖尿病监测的智能可穿戴传感器。

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