Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging

机译：非对称检测时间拉伸光学显微镜（ATOM），用于高对比度和高速微流细胞成像

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High-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, asymmetric-detection time-stretch optical microscopy (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy - a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM - achieving an imaging throughput equivalent to ～100,000 cells/sec.

机译：高通量细胞成像在生物医学诊断中令人着迷，但具有挑战性。通过结合一种简单的检测方案，我们证明了一种新的成像方式，不对称检测时间拉伸光学显微镜（ATOM），这是时间拉伸显微镜的进一步发展-一种实现高速和高通量细胞的可行解决方案成像。通过ATOM中的非对称检测方案，通过访问相位梯度信息可以增强时间拉伸图像的对比度。通过在1μm波长范围内的操作，我们演示了ATOM在超快微流体流（高达10 m / s）中的高分辨率和高对比度细胞成像-实现了相当于100,000个细胞/秒的成像吞吐率。

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来源
《Imaging, manipulation, and analysis of biomolecules, cells, and tissues XII》|2014年|89471D.1-89471D.6|共6页
会议地点 San Francisco CA(US)
作者
Terence T. W. Wong; Andy K. S. Lau; Matthew Y. H. Tang; Kenneth K Y. Ho; Kenneth K. Y. Wong; Anderson H. C. Shum; Kevin K. Tsia;
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作者单位

Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China;

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正文语种 eng
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time-stretch imaging; high-speed microfluidic; cell imaging; ultrafast frame rate; biophotonics; imaging flow cytometry; high-throughput;

机译：时间拉伸成像高速微流；细胞成像；超快帧率；生物光子学成像流式细胞仪高通量;

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专利

1. Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow [J] . Terence T. W. Wong, Andy K. S. Lau, Kenneth K. Y. Ho, Scientific reports. . 2014,第1期

机译：非对称检测时间拉伸光学显微镜（ATOM）用于流动中的超快速高对比度细胞成像
2. High-throughput microfluidic particle velocimetry using optical time-stretch microscopy [J] . Ding Yingchun, Yu Liqi, Zhang Chaomin, Applied Physics Letters . 2019,第3期

机译：使用光学时间拉伸显微镜的高通量微流控颗粒测速
3. High-throughput microfluidic particle velocimetry using optical time-stretch microscopy [J] . Ding Yingchun, Yu Liqi, Zhang Chaomin, Applied Physics Letters . 2019,第3期

机译：使用光学时间拉伸显微镜的高通量微流体粒子速度
4. High-throughput cellular imaging with high-speed asymmetric-detection time-stretch optical microscopy under FPGA platform [C] . Ho-Cheung Ng, Maolin Wang, Bob M.F. Chung, International Conference on Reconfigurable Computing and FPGAs . 2016

机译：FPGA平台下具有高速非对称检测时间拉伸光学显微镜的高通量细胞成像
5. Phonic Time-Stretch for High-Speed Analog-to-Digital Conversion and Imaging [D] . Motafakker-Fard, Ali. 2011

机译：语音时间拉伸，用于高速模数转换和成像
6. Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM) [O] . Anson H. L. Tang, Queenie T. K. Lai, Bob M. F. Chung, 2017

机译：微流体成像流式细胞仪通过不对称检测时间拉伸光学显微镜（ATOM）
7. Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging [O] . Tsia KKM, Ho KY, Shum HC, 2014

机译：非对称检测时间拉伸光学显微镜（aTOm），用于高对比度和高速微流体细胞成像

Asymmetric-detection time-stretch optical microscopy (ATOM) for high-contrast and high-speed microfluidic cellular imaging

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