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首页> 外文会议>Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI >Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier
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Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

机译：胰岛素包覆的金纳米颗粒作为绕过血脑屏障的有效方法

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摘要

A major challenge for treatment of neurodegenerative disorders is the need to overcome the restrictive mechanismof the blood-brain-barrier (BBB) for delivery of therapeutic agents into the brain. Our goal was to develop an efficientnanoparticle-based system with the ability to bypass the BBB by targeting insulin receptors. We demonstrate that insulincoatedgold-nanoparticles (INS-GNPs) can serve as an effective endogenous BBB transport system for deliveringtherapeutics into the brain. We further conducted a quantitative in-vivo investigation of the effect of nanoparticle size(20, 50 and 70nm) on the ability of INS-GNPs to cross the BBB. The most widespread bio-distribution and highestaccumulation within the brain (5% of the injected dose) was observed using 20nm INS-GNPs, two hours post-injection.In-vivo CT imaging revealed that particles migrated to specific brain regions, rich in insulin receptors, which areimportant targets for the treatment of various neurodegenerative disorders. The findings described herein suggest thepotential beneficial use of INS-GNPs as nano-vehicles for the transport of drugs through the BBB.
机译：治疗神经退行性疾病的主要挑战是需要克服血脑屏障（BBB）的限制性机制，无法将治疗剂输送到大脑。我们的目标是开发一种有效的基于纳米颗粒的系统，该系统具有通过靶向胰岛素受体来绕过BBB的能力。我们证明胰岛素涂层的\ n \ n金纳米颗粒（INS-GNPs）可以作为一种有效的内源性BBB转运系统，用于向脑内输送\ r \ n治疗药物。我们进一步进行了体内定量研究，研究了纳米粒径\ r \ n（20、50和70nm）对INS-GNPs穿越BBB能力的影响。注射后两个小时，使用20nm INS-GNPs观察到了最广泛的生物分布和最高的脑内蓄积（注射剂量的5％）。\ r \ n体内CT成像显示颗粒迁移至富含胰岛素受体的特定大脑区域，是治疗各种神经退行性疾病的重要目标。本文描述的发现表明，INS-GNP作为纳米载体的潜在有益用途是通过BBB转运药物。

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  • 会议地点 2410-9045;1605-7422
  • 作者

    Oshra Betzer; Malka Shilo; Menachem Motiei; Rachela Popovtzer;

  • 作者单位

    Faculty of Engineering and the Institutes of Nanotechnology Advanced Materials, Bar-Ilan University,Ramat-Gan, 52900, Israel;

    George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, 69978, Israel;

    Faculty of Engineering and the Institutes of Nanotechnology Advanced Materials, Bar-Ilan University,Ramat-Gan, 52900, Israel;

    Faculty of Engineering and the Institutes of Nanotechnology Advanced Materials, Bar-Ilan University,Ramat-Gan, 52900, Israel;

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