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首页> 外文会议>Instruments, methods, and missions for astrobiology XIV >Diverse nucleotide compositions and sequence fluctuation in Rubisco protein genes
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Diverse nucleotide compositions and sequence fluctuation in Rubisco protein genes

机译：Rubisco蛋白基因的不同核苷酸组成和序列波动

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The Rubisco protein-enzyme is arguably the most abundance protein. Stronger correlation of fractal dimension of the atomic number fluctuation along a DNA sequence with Shannon entropy has been observed in the studied Rubisco-like gene sequences, suggesting a more diverse evolutionary pressure and constraints in the Rubisco sequences. The strategy of using metal for structural stabilization appears to be an ancient mechanism, with data from the porphobilinogen deaminase gene in Capsaspora owczarzaki and Monosiga brevicollis. Using the chi-square distance probability, our analysis supports the conjecture that the more ancient Rubisco-like sequence in Microcystis aeruginosa would have experienced very different evolutionary pressure and bio-chemical constraint as compared to Bordetella bronchiseptica, the two microbes occupying either end of the correlation graph where the free energy of secondary structure as calculated by NUPACK was found to be also correlated with the fractal dimension (adjusted R-square ～ 0.981). The equation "free energy = proportionality constant * fractal dimension + intercept" could be useful to represent various classes of rubisco-like sequences, each class has its own equation coefficients. Sulfur pathway Rubisco-like sequences could have been used by sulfur based life process 3.4 billion years ago on Earth, and possibility elsewhere. Our exploratory study would indicate that high fractal dimension Rubisco sequence would support high carbon dioxide rate via the Michaelis-Menten coefficient; with implication for the control of the whooping cough pathogen Bordetella bronchiseptica, a microbe containing a high fractal dimension Rubisco-like sequence (2.07). Using the internal comparison of chi-square distance probability for 16S rRNA (～ E-22) versus radiation repair Rec-A gene (～E-05) in high GC content Deinococcus radiodurans, our analysis supports the conjecture that high GC content microbes containing Rubisco-like sequence are likely to include an extra-terrestrial origin, relative to Deinococcus radiodurans.
机译：Rubisco蛋白酶可以说是最丰富的蛋白。在研究的Rubisco-like基因序列中，观察到沿着DNA序列的原子序数波动的分形维数与香农熵之间的相关性更强，这表明Rubisco序列的进化压力和限制条件更加多样化。利用金属进行结构稳定的策略似乎是一种古老的机制，其数据来自Capsaspora owczarzaki和Monosiga brevicollis中的胆色素原脱氨酶基因。使用卡方距离概率，我们的分析支持这样的推测，即与支气管败血博德特氏菌相比，铜绿微囊藻中更古老的Rubisco-like序列将经历非常不同的进化压力和生化限制，这两种微生物分别占据了支气管败血病的两端。通过NUPACK计算得到的二级结构的自由能也与分形维数相关（校正后的R平方〜0.981）。等式“自由能=比例常数*分形维+截距”对于表示各种类Rubisco序列很有用，每种类都有自己的等式系数。硫的途径像Rubisco一样的序列早在34亿年前就已经被地球上基于硫的生命过程所使用，并可能在其他地方被使用。我们的探索性研究表明，高分形维Rubisco序列将通过Michaelis-Menten系数支持高二氧化碳速率；对控制百日咳病原体支气管败血波氏杆菌具有重要意义，这种微生物含有高分形维Rubisco样序列（2.07）。使用内部比较高GC含量的Deinococcus radiodurans中16S rRNA（〜E-22）与放射修复Rec-A基因（〜E-05）的卡方距离概率，我们的分析支持以下推测：相对于放射硬核球菌，Rubisco样序列可能包括地球外起源。

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