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首页> 外文会议>International Joint Conference on Neural Networks;IJCNN 2009 >Intelligent clinical decision supports for interferon treatment in chronic hepatitis C and B based on i-biopsy™
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Intelligent clinical decision supports for interferon treatment in chronic hepatitis C and B based on i-biopsy™

机译：基于i-biopsy™的智能临床决策支持对慢性丙型和乙型肝炎的干扰素治疗

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摘要

In chronic hepatitis C and B, which can progress to cirrhosis and liver cancer, Interferon is the only effective treatment, for carefully selected patients, but it is very expensive. Some of the selection criteria are based on liver biopsy, an invasive, costly and painful medical procedure. Developing an efficient selection system, based on non-invasive medical procedures, could be in the patients benefit and also save money. We investigated the capability of a knowledge discovery in data approach, using computational intelligence tools, to integrate information from various non-invasive data sources - imaging, clinical, and laboratory data - to assist the interferon therapeutical decision, mainly by predicting with acceptable accuracy the results of the biopsy. The resulted intelligent systems, tested on 700 patients with chronic hepatitis C and 500 patients with chronic hepatitis B, based on C5.0 decision trees and boosting, predict with 100% accuracy the results of the liver biopsy. Also, by integrating other patients selection criteria, they offer a non-invasive support for the correct Interferon therapeutic decision. To our best knowledge, these decision systems outperformed all similar systems published in the literature and offer a realistic opportunity to replace liver biopsy in this medical context.
机译：在可能发展为肝硬化和肝癌的慢性丙型和乙型肝炎中，对于精心挑选的患者，干扰素是唯一有效的治疗方法，但它非常昂贵。一些选择标准基于肝活检，这是一种侵入性，昂贵且痛苦的医疗程序。基于无创医疗程序开发有效的选择系统，可能会使患者受益，也可以节省金钱。我们研究了使用计算智能工具在数据方法中发现知识的能力，以整合来自各种非侵入性数据源（成像，临床和实验室数据）的信息来辅助干扰素治疗，主要是通过以可接受的准确性进行预测活检的结果。最终的智能系统基于C5.0决策树和增强功能，在700例慢性丙型肝炎患者和500例慢性乙型肝炎患者中进行了测试，以100％的准确性预测肝活检的结果。而且，通过整合其他患者的选择标准，他们为正确的干扰素治疗决策提供了非侵入性支持。据我们所知，这些决策系统的性能优于文献中公布的所有类似系统，并为在这种医学背景下替代肝活检提供了现实的机会。

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