ELUCIDATING THE MECHANISM OF ESCAPE OF POLYETHYLENIM-INE/RIBOZYME COMPLEXES FROM THE LYSOSOMAL COMPARTMENT

机译：从溶酶体隔室中洗脱聚乙烯亚胺/核酶复合物的逃逸机理

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The mechanism of escape of polyethylen-imine(PEI)/ribozyme complexes from the ly-sosomal compartment has been investigated by dual color living cell confocal laser scanning microscopy and transfection experiments. The data provides strong evidence that release occurs through lysosomal burst.

机译：通过双色活细胞共聚焦激光扫描显微镜和转染实验研究了聚乙烯亚胺（PEI）/核酶复合物从溶酶体区室逃逸的机理。数据提供了有力证据表明释放是通过溶酶体爆发发生的。

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来源
《International symposium on controlled release of bioactive materials;Consumer diversified products conference》|2001年|p.1137-1138|共2页
会议地点 San Diego CA(US);San Diego CA(US)
作者
T. Merdan; K. Kunath; D. Fischer; T. Kissel;
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Department of Pharmaceutics and Biopharmacy Philipps-University D-35037 Marburg Germany;

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关键词
polyethylenimine; confocal microscopy; gene therapy; release;

机译：聚乙烯亚胺;共聚焦显微镜基因治疗;释放;

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2. SURVEY AND SUMMARY: Recent advances in the elucidation of the mechanisms of action of ribozymes. [J] . Takagi Y, Warashina M, Stec WJ, Nucleic Acids Research . 2001,第9期

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ELUCIDATING THE MECHANISM OF ESCAPE OF POLYETHYLENIM-INE/RIBOZYME COMPLEXES FROM THE LYSOSOMAL COMPARTMENT

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