Surface decoration with gH625-membranotropic peptides as a method to escape the endo-lysosomal compartment and reduce nanoparticle toxicity

Guarnieri D.; Muscetti O.; Falanga A.; Fusco S.; Belli V.; Perillo E.; Battista E.; Panzetta V.; Galdiero S.; Netti P. A.

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Surface decoration with gH625-membranotropic peptides as a method to escape the endo-lysosomal compartment and reduce nanoparticle toxicity

机译：用gH625-亲膜肽进行表面修饰，作为逃逸溶酶体区室并降低纳米颗粒毒性的方法

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The membranotropic peptide gH625 is able to transport different cargos (i.e., liposomes, quantum dots, polymeric nanoparticles) within and across cells in a very efficient manner. However, a clear understanding of the detailed uptake mechanism remains elusive. In this work, we investigate the journey of gH625-functionalized polystyrene nanoparticles in mouse-brain endothelial cells from their interaction with the cell membrane to their intracellular final destination. The aim is to elucidate how gH625 affects the behavior of the nanoparticles and their cytotoxic effect. The results indicate that the mechanism of translocation of gH625 dictates the fate of the nanoparticles, with a relevant impact on the nanotoxicological profile of positively charged nanoparticles.

机译：促膜肽gH625能够以非常有效的方式在细胞内和跨细胞运输不同的货物（即脂质体，量子点，聚合物纳米颗粒）。但是，对详细的摄取机制的清晰了解仍然难以捉摸。在这项工作中，我们调查了gH625-官能化的聚苯乙烯纳米颗粒在小鼠脑内皮细胞中的作用，即它们从与细胞膜的相互作用到细胞内最终目的地的过程。目的是阐明gH625如何影响纳米颗粒的行为及其细胞毒性作用。结果表明，gH625的易位机制决定了纳米颗粒的命运，对带正电荷的纳米颗粒的纳米毒理学特性具有重要影响。

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《Nanotechnology》 |2015年第41期|共12页
作者
Guarnieri D.; Muscetti O.; Falanga A.; Fusco S.; Belli V.; Perillo E.; Battista E.; Panzetta V.; Galdiero S.; Netti P. A.;
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正文语种 eng
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nanoparticles; membranotropic peptides; intracellular fate; lysosomes; nanotoxicity;

机译：纳米颗粒;促膜肽;细胞内命运;溶酶体;纳米毒性;

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1. Surface decoration with gH625-membranotropic peptides as a method to escape the endo-lysosomal compartment and reduce nanoparticle toxicity [J] . Guarnieri D., Muscetti O., Falanga A., Nanotechnology . 2015,第41期

机译：用gH625-亲膜肽进行表面修饰，作为逃逸溶酶体区室并降低纳米颗粒毒性的方法
2. The pathway for MHCII-mediated presentation of endogenous proteins involves peptide transport to the endo-lysosomal compartment. [J] . Dani A, Chaudhry A, Mukherjee P, Journal of Cell Science . 2004,第Pta18期

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3. Facile decoration of Au nanoparticles on reduced graphene oxide surfaces via a one-step chemical functionalization approach [J] . Haiqing Yao, Lin Jin, Hung-Jue Sue Journal of Materials Chemistry, A. Materials for energy and sustainability . 2013,第36期

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4. Enzymatic cell-surface decoration with a functional protein using amphiphilic lipid-fused peptide substrates [C] . Mari Takahara, Naoki Fujimoto, Rie Wakabayashi 日本化学会春季年会講演予稿集 . 2018

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7. Rapid synthesis and decoration of reduced graphene oxide with gold nanoparticles by thermostable peptides for memory device and photothermal applications [O] . Otari, Sachin V, Kumar, Manoj, Anwar, Muhammad Zahid, 2017

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Surface decoration with gH625-membranotropic peptides as a method to escape the endo-lysosomal compartment and reduce nanoparticle toxicity

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