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首页> 外文会议>International symposium on halogenated persistent organic pollutants >1-NAPHTHYLAMINE AND 2-NAPHTHYLAMINE IN HUMAN URINE RELEVANT TO THE LIFESTYLE IN NEPAL
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1-NAPHTHYLAMINE AND 2-NAPHTHYLAMINE IN HUMAN URINE RELEVANT TO THE LIFESTYLE IN NEPAL

机译：尿中与生活方式有关的人尿中的1-萘胺和2-萘胺

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摘要

Stir bar sorptive extraction (SBSE) coupled with thermal desorption unit (TDU)-gas chromatography–mass spectrometry (GC–MS) (SBSE-TDU-GC-MS) was applied to detect poly aromatic hydrocarbon (PAH) especially 1-Naphthylamine (1-NA) and 2-naphthylamine (2-NA) in 138 human urine samples. A stir bar coated with polydimethylsiloxane (PDMS) is added to a 1ml urine sample and stirring is carried out for 60 min at room temperature (25 ℃) in a vial. Then, the PDMS stir bar is subjected to TDU–GC–MS. Urine samples without and with enzymaticde-conjugation were analyzed. Results show that, in the urine samples without enzymaticde-conjugation, 1-NA was detected in 58 samples. In contrast, in the samples treated with (β)-glucuronidase, it was detected in 90 samples. These results indicate that most of 1-NA and 2-NA presented as conjugate in the urine samples. In addition, it is found that 1-NA and 2-NA presence is closely related to the lifestyle of the people and it is independent on gender, age and body-mass index (BMI).
机译：搅拌棒吸附萃取（SBSE）结合热脱附单元（TDU）-气相色谱-质谱（GC-MS）（SBSE-TDU-GC-MS）用于检测多芳烃（PAH），尤其是1-萘胺（ 138个人类尿液样本中的1-NA）和2-萘胺（2-NA）。将涂有聚二甲基硅氧烷（PDMS）的搅拌棒添加到1ml尿液样品中，并在室温（25℃）的小瓶中搅拌60分钟。然后，将PDMS搅拌棒进行TDU-GC-MS处理。分析没有和有酶促结合的尿液样品。结果显示，在没有酶促结合的尿液样本中，在58个样本中检测到1-NA。相反，在用（β）-葡糖醛酸糖苷酶处理的样品中，在90个样品中检测到了它。这些结果表明，在尿液样品中大多数1-NA和2-NA作为结合物存在。此外，发现1-NA和2-NA的存在与人们的生活方式密切相关，并且与性别，年龄和身体质量指数（BMI）无关。

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