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首页> 外文会议>International symposium on halogenated persistent organic pollutants >PHOTOELECTROCHEMICAL DETECTION OF DNA-TFBQ ADDUCTS AND DNA OXIDATIVE DAMAGE INDUCED BY NOVEL HO?THAT INDEPENDENT OF METAL IONS
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PHOTOELECTROCHEMICAL DETECTION OF DNA-TFBQ ADDUCTS AND DNA OXIDATIVE DAMAGE INDUCED BY NOVEL HO?THAT INDEPENDENT OF METAL IONS

机译：金属离子无关性引起的DNA-TFBQ添加剂的光化学检测和DNA氧化损伤

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摘要

Pentachlorophenol itself does not show any reactivity to DNA, but its final metabolite, tetrachloro-1,4-benzoquinone (TCBQ), has the capacity to damage DNA by forming DNA adducts. Furthermore, it had been reported that TCBQ or other halogenated quinones could produce hydroxyl radical (HO·) in the presence of H2O2 independent of transition metal ions. In this report, TFBQ (tetrafluoro-1,4-benzoquinone) as a model compound of TCBQ was first investigated because of its better activity. The photoelectrical DNA sensor we have previously reported can efficiently detect DNA adducts with 100 μM TFBQ and DNA oxidative damage induced by 100 μM TFBQ / 2 mM H2O2. Compared to gel electrophoresis, the sensor is more sensitive to detect the DNA oxidative damage, and DNA adducts can be obviously detected in the photoelectrochemical experiment.
机译：五氯苯酚本身对DNA没有任何反应性，但其最终代谢产物四氯-1,4-苯醌（TCBQ）具有通过形成DNA加合物来破坏DNA的能力。此外，据报道，在过氧化氢存在下，TCBQ或其他卤代醌可产生羟基自由基（HO·），而与过渡金属离子无关。在本报告中，由于其更好的活性，首次研究了TFBQ（四氟-1,4-苯醌）作为TCBQ的模型化合物。我们之前报道的光电DNA传感器可以有效检测100μMTFBQ的DNA加合物和100μMTFBQ / 2 mM H2O2诱导的DNA氧化损伤。与凝胶电泳相比，该传感器对DNA氧化损伤的检测更为灵敏，并且在光电化学实验中可以明显地检测到DNA加合物。

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