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首页> 外文会议>International Academic Conference on Environmeatal amp; Occupational Medicine; 20041110-12; Shanghai(CN) >Antimicrobial Resistance in Neisseria Gonorrhoeae Isolated from Patients in Jiangsu Province, China
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Antimicrobial Resistance in Neisseria Gonorrhoeae Isolated from Patients in Jiangsu Province, China

机译：江苏省患者淋病奈瑟菌的耐药性

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[Objective] To realize antibiotic resistance amongst Neisseria gonorrhoeae isolated from patients in different cities of Jiangsu province, in order to instruct correct treatment in gonorrhea infection. [Methods] The in-vitro susceptibility test was performed in 95 strains of N. gonorrhoeae. The Minimum inhibitory concentrations(MICs) of penicillin, tetracycline,ciprofloxacin,levofloxacin,cef-triaxone, cefotaxime, cefepime and spectinomycin were determined by agar dilution test using GC agar base containing 1% defined supplement and serial dilutions of each agent. PPNG were identified by commercial strips for detection of β-lactamase.TRNG were identified by strains' MIC.TEM gene and TetM gene were detected by PCR assay. [Results] There were 57 isolates of N. gonorrhoeae from Nanjing, 53 from Wuxi and 15 from Xuzhou. In all, there were 101(80.8%) from symptomatic men and24(19.2%) from symptomatic women. Therefore, ciprofloxacin resistance was 100%, tetracycline resistance was 78.9%, and penicillin resistance was 68.4%, while spectinomycin resistance was detected as 1.1%. No resistance was detected against the third generation cephalosporines, including ceftriaxone, cefotaxime and cefepime. Of the 95 isolates, 52(54.7%) were PPNG and penicillin MIC_(50) was 64μg/ml,27(28.4%) were TRNG and tetracycline MIC50 was 32μg/ml. PPNG had high level TEM gene(96.3%) and TRNG had high level TetM gene(93.3%). [Conclusion] Antimicrobial resistance of N. gonorrhoeae was more serious in Jiangsu province. Ciprofloxacin may become a useless drug to treat gonorrhea infection in this province.
机译：［目的］实现江苏省不同城市分离的淋病奈瑟菌的耐药性，指导正确治疗淋病。 ［方法］对95株淋病奈瑟菌进行了体外药敏试验。青霉素，四环素，环丙沙星，左氧氟沙星，头孢曲松，头孢噻肟，头孢吡肟和壮观霉素的最小抑菌浓度（MICs）通过琼脂稀释试验确定，使用含有1％规定补充剂的GC琼脂基质和每种试剂的连续稀释度。用商用试纸条鉴定PPNG，检测β-内酰胺酶。用菌株MIC.TEM基因鉴定TRNG，用PCR法检测TetM基因。结果南京分离出淋病奈瑟菌57株，无锡53株，徐州15株。总的来说，有症状的男性有101（80.8％），有症状的女性有24（19.2％）。因此，环丙沙星抗性为100％，四环素抗性为78.9％，青霉素抗性为68.4％，而壮观霉素抗性为1.1％。没有检测到对第三代头孢菌素（包括头孢曲松，头孢噻肟和头孢吡肟）的耐药性。在这95株菌株中，PPNG占52（54.7％），青霉素MIC_（50）为64μg/ ml，TRNG占27（28.4％），四环素MIC50为32μg/ ml。 PPNG具有高水平的TEM基因（96.3％），TRNG具有高水平的TetM基因（93.3％）。 ［结论］江苏省淋病奈瑟菌的耐药性较严重。环丙沙星可能成为该省治疗淋病感染的无用药。

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