摘要:从链霉菌335的发酵液中分离得到2个具有免疫抑制活性的组分-抗生素335A1和335A4,基于其各种光谱分析对结构的阐明,抗生互335A4为4-[2-(3S,5R-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperdinedinoe,抗生素335A1为4-[2-(3S,5S-dimethyl-2-oxoxcylclohexyl)-2-hydroxyethyl]-2,6-piperdinedione和4-[2-(3R,5S-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-peperdinedione的混合体,335A1具有较强的免疫抑制活性。