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首页> 外文会议>International conference on advancements of medicine and health care through technology >Clinical Experience with a Macroporous Synthetic Bone Substitute (Eurocer~®) in the Treatment of the Patients with Bone Defects
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Clinical Experience with a Macroporous Synthetic Bone Substitute (Eurocer~®) in the Treatment of the Patients with Bone Defects

机译：大孔合成骨替代品（Eurocer〜®）治疗骨缺损患者的临床经验

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The treatment of bone defects was a major chal lenge and may still be a problem today. Due to the disadvan tages with biologically bone grafts there is a high clinical de mand for synthetic bone substitution materials. The aim of this prospective study is to reveal biocompatibility integration and extension of osseous healing for a biphasic synthetic ceramic bone substitute (Eurocer), when used in the treatment of 31patients with 33 bone defects (fractures, nonunions, os teoarthritis). Eurocer~® (FH Orthopaedics France) is an osteo conductive ceramic material representing a mixture of 55% hydroxyapatite and 45% tricalcium-phosphate and is available in granular form and in various geometric shapes. The authors used GESTO (Greffes et Substitutes Tissulaires en Orthope die) protocol for preoperative selection and postoperative follow-up. The mean defect volume for all defects treated with Eurocer was 12cc. According to the size and type of defects the authors used Eurocer~® as a single component or mixed with autologous bone graft Stabilization was achieved by internal fixation in all operation except one (a fracture of hu meral head). We have used for osteosynthesis classic plates or plates with angular stability, especially in compression frac tures associated with osteoporosis. All patients have been fol lowed-up clinically and radiologic for 2, 3, 4, 6, 9, 12 and 18 months post-operative. The mean time to clinically healing was 3.2 months while the mean time to radiographic healing was 4.5 months. We observed no implant fragmentation and no local inflammation or sepsis. Due to minimally invasive sur gery and fast rehabilitation, no joint stiffness or limited joint motion was recorded. This prospective study demonstrates that the biphasic synthetic ceramic material Eurocer~® is an effective bone graft substitute for usage in patients with bone defects. To insure a consistent result it is mandatory to strictly follow the three requirements for osteoconduction: proximity, viability and stability.
机译：骨缺损的治疗是一项重大挑战，今天可能仍然是一个问题。由于使用生物骨移植物的不适，对合成骨替代材料的临床需求很高。这项前瞻性研究的目的是揭示一种双相合成陶瓷骨替代物（Eurocer）在治疗31例具有33例骨缺损（骨折，骨不连，骨关节炎）的患者时的生物相容性整合和骨愈合的扩展。 Eurocer®（FH Orthopedics France）是一种骨传导陶瓷材料，代表55％的羟基磷灰石和45％的磷酸三钙的混合物，有颗粒状和各种几何形状。作者采用GESTO（Greffes等人的《 Orthope die》杂志上的Tissulaires替代品）方案进行术前选择和术后随访。使用Eurocer处理的所有缺陷的平均缺陷量为12cc。根据缺损的大小和类型，作者使用Eurocer®作为单一组分或与自体骨移植物混合，除一个手术（肱骨头骨折）外，所有手术均通过内固定实现稳定。我们已将经典的骨板或具有角度稳定性的板用于骨合成，尤其是在与骨质疏松症相关的压缩骨折中。所有患者均经过术后2、3、4、6、9、12和18个月的临床和放射学检查。临床上的平均康复时间为3.2个月，而放射学上的平均康复时间为4.5个月。我们没有观察到植入物碎片，也没有局部发炎或败血症。由于微创手术和快速康复，未记录到关节僵硬或关节活动受限。这项前瞻性研究表明，两相合成陶瓷材料Eurocer®是骨缺损患者使用的有效骨移植替代物。为了确保结果一致，必须严格遵守骨传导的三个要求：接近性，生存力和稳定性。

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