Objective To evaluate the effect of acellular dermal matrix(ADM) on guided bone regeneration(GBR) of the defects of jaw bone. Methods We collected 42 patients with bone defect of the recipient site before implantation visiting the department of stomatology of Chengdu Military Region Hospital of The People’s Liberation Army, and then used domestic ADM GBR to repair jaw bone defect. Examed with X-ray six months postoperatively, and compared the results with that of the GBR preoperatively. Then we implanted in the osteogenesis area, observated the bone formation conditions, made histopathologic study for new bone from implanting. Results 42 patients after review of nonsignificant do not have between -group rejection. Phase of 40 patients underwent surgical process observation osteogenesis result is satisfactory, and planting primary stability is better without residual film. Histology observations show that there are obvious slice of bone formation, because of wound infection. One late osteoblast effect is satisfactory after repeated washing area with antibiotics. The other is failure. Conclusion The effect of GBR with ADM for repairing oral maxillofacial bone defect is definite.% 目的对异种脱细胞真皮基质(ADM)在应用引导骨再生(GBR)治疗种植义齿受植区骨缺损中成骨的效果进行评价,以确定 ADM 是否能够在 GBR 术中有成骨作用.方法收集中国人民解放军成都军区机关医院口腔科就诊的种植前受植区颌骨骨缺损的患者42例为研究对象,采用国产异种 ADM 进行 GBR 术修复颌骨骨缺损,6个月后行 X 线检查,并与 GBR 术前进行比较,成骨区行种植术,观察术中骨生成的情况,将种植过程中取出的新生骨进行组织学观察.结果42例患者在术后复查中未见明显排异反应.其中,40例患者行二期手术过程中观察成骨效果满意,种植体初期稳定性较好,未见残留膜.切片组织学观察可见明显板层骨形成.2例患者因为创口感染,经过术区抗生素反复冲洗,控制感染后,1例后期成骨效果较满意,1例失败.结论异种 ADM 应用于 GBR修复种植义齿受植区骨缺损,成骨效果肯定.
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