Magnetically Targeted Drug Transport and Fixation

机译：磁性靶向药物的运输和固定

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摘要

This paper presents a mathematical model and numerical simulation results on transport and targeting of a medical substance carried by magnetic nanoparticles through a high gradient magnetic field. In our study we use simpler yet consistent models for the hemodynamic flow, and more complex, realistic computational domains based on medical images for the iliac arterial branching. The biocompatible drug carrier is injected in the blood. An optimized array of permanent magnets generates the targeting magnetic field, in the process of medication delivery in the region of therapeutic concern.

机译：本文介绍了磁性纳米颗粒通过高梯度磁场传输和靶向药物的数学模型和数值模拟结果。在我们的研究中，我们使用更简单但一致的模型进行血流动力学分析，并基于医学图像为ilia动脉分支使用更复杂，更实际的计算域。生物相容性药物载体被注入血液中。在治疗关注区域中的药物输送过程中，优化的永磁体阵列会产生目标磁场。

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来源
《International conference on advancements of medicine and health care through technology》|2011年|p.310-315|共6页
会议地点 Cluj-Napoca(RO);Cluj-Napoca(RO)
作者
A.A. Dobre; A.M. Morega; M. Morega;
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作者单位

Faculty of Electrical Engineering, University POLITEHNICA of Bucharest, Bucharest, Romania;

Faculty of Electrical Engineering, University POLITEHNICA of Bucharest, Bucharest, Romania,"Gheorghe Mihoc - Caius Iacob" Institute of Mathematical Statistic and Applied Mathematics, Romanian Academy;

Faculty of Electrical Engineering, University POLITEHNICA of Bucharest, Bucharest, Romania;

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会议组织
原文格式 PDF
正文语种 eng
中图分类保健组织与事业（卫生事业管理）;
关键词
magnetic drug targeting; flow - magnetic field interaction; numerical simulation; optimization;

机译：磁性药物靶向流-磁场相互作用；数值模拟优化;

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专利

1. Influence of local particle concentration gradient forces on the flow-mediated mass transport in a numerical model of magnetic drug targeting [J] . Veronica C. Gonella, Friedrich Hanser, Johannes Vorwerk, Journal of magnetism and magnetic materials . 2021,第May期

机译：局部颗粒浓度梯度力对磁性药物靶向数值模型中流动介导的大规模转运的影响
2. Implant-assisted magnetic drug targeting in permeable microvessels: Comparison of two-fluid statistical transport model with experiment [J] . ChiBin Zhang, XiaoHui Lin, Zhaomin Wang, Journal of magnetism and magnetic materials . 2017,第mara期

机译：渗透性微血管中的植入物辅助磁性药物靶向：双流体统计转运模型与实验的比较
3. Transferrin‐conjugated magnetic dextran‐spermine nanoparticles for targeted drug transport across blood‐brain barrier [J] . Ghadiri Maryam, Vasheghani‐Farahani Ebrahim, Atyabi Fatemeh, Journal of biomedical materials research, Part A . 2017,第10期

机译：转铁蛋白缀合的磁性葡聚糖 - 精乳胺纳米粒子，用于血脑屏障的靶向药物转运
4. Modeling and Simulation of Magnetic Nanoparticles Transport in a Channel for Magnetic Drug Targeting [C] . SHASHI SHARMA, ANURAG GAUR, UADAY SINGH, International Conference on Fluid Mechanics and Heat Mass Transfer . 2014

机译：磁性药物靶向通道中磁性纳米粒子输送的建模与仿真
5. Magnetic drug targeting: Development of a novel drug delivery system for prostate cancer therapy. [D] . Rahimi, Maham. 2008

机译：磁性药物靶向：开发用于前列腺癌治疗的新型药物递送系统。
6. Iron oxide-doped niosomes as drug carriers for magnetically targeted drug delivery [O] . Ridhima Juneja, Indrajit Roy 2018

机译：氧化铁掺杂的脂质体作为磁性靶向药物输送的药物载体
7. A Model for Magnetic Nanoparticles Transport in a Channel for Targeted Drug Delivery [O] . Sharma Shashi, Kumar Ravi, Gaur Anurag 2015

机译：靶向药物输送通道中磁性纳米颗粒的运输模型。
8. Magnetically responsive microparticles for targeted drug and radionuclide delivery. [R] . 2004

机译：用于靶向药物和放射性核素递送的磁性响应微粒。

Magnetically Targeted Drug Transport and Fixation

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