• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of magnetism and magnetic materials >Influence of local particle concentration gradient forces on the flow-mediated mass transport in a numerical model of magnetic drug targeting
【24h】

Influence of local particle concentration gradient forces on the flow-mediated mass transport in a numerical model of magnetic drug targeting

机译：局部颗粒浓度梯度力对磁性药物靶向数值模型中流动介导的大规模转运的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Magnetic nanoparticles have been widely applied in the nanomedicine field: therapies based on magnetic drug targeting have shown promising results towards the improvement of the current state of the art of medical treatments. Particles interaction with their carrying flow or the surrounding tissues still needs to be completely understood,as well as the mechanisms underlying interparticle interactions. These interactions can potentially promote particles aggregation in the fluid doman and therefore influence the therapy outcome. This study presents a numerical model to describe particles magnetohydrodynamics in a realistic setup for magnetic drug targeting. The focus is a quantitative analysis of the contribution of the local ferrofluid concentration gradients to the magnetic fluid volume force,as well as an investigation on the dependence of the magnetic fluid volume force on particles diameter and ferrofluid concentration. The results show that the main contribution to the magnetic fluid volume force is the magnetic field gradients term. However,the concentration gradients term ranges in the same order of magnitude and therefore cannot be neglected in the force formulation. In addition,the molar concentration distribution has been found to change with different force formulations and with different values of the molar influx too. The model outlines that the magnetic fluid volume force increases with the particle diameter and the ferrofluid concentration. However,both relationships are not linear,but more complex. The described approach proves to be versatile and further applicable to more complex geometries and scenarios. In addition,the outcome and the achievements of the presented numerical model provide for the first time insights into the role of the local ferrofluid concentration gradients in the determination of the magnetic fluid volume force and represent a starting point for further investigations of the mechanisms underlying the flow-mediated ferrofluid mass transport.
机译：磁性纳米颗粒已广泛应用于纳米美床领域：基于磁性药物靶向的疗法表明了对改善医疗治疗领域的最新状态的有希望的结果。颗粒仍然需要完全理解与其承载流或周围组织的相互作用，以及底下相互作用的机制。这些相互作用可以潜在地促进流体多米南的颗粒聚集，从而影响治疗结果。本研究提出了一种数字模型，用于描述磁性药物靶向的熟肉磁流体动力学。重点是对局部铁磁流体浓度梯度对磁性流体体积力的贡献的定量分析，以及对磁性流体体积力对颗粒直径和铁磁流体浓度的依赖性的研究。结果表明，磁性流体体积力的主要贡献是磁场梯度术语。然而，浓度梯度术语术语在相同的数量阶范围，因此在力制剂中不能忽略。此外，已经发现摩尔浓度分布以不同的力制剂和摩尔流入的不同值改变。该模型概述了磁性流体体积力随粒径和铁磁流体浓度而增加。但是，这两个关系都不是线性的，但更复杂。所描述的方法证明是通用的，进一步适用于更复杂的几何形状和情景。此外，所提出的数值模型的结果和成果提供了第一次见解局部铁磁流体浓度梯度在磁性流体体积力的测定中的作用，并且代表了进一步研究所下面的机制的起点流动介导的铁磁流体传输。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号