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Integration of the Calcium Dynamics in the Excitation Contraction Coupling Process within a Multiscale Model of the Left Ventricle

机译:左心室多尺度模型中兴奋收缩耦合过程中钙动力学的积分。

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摘要

The description of multiscale processes in a uni fied and coherent fashion is of paramount importance in car diovascular computational physiology. In this paper, a model that links the process of cardiac excitation and contraction from a cellular to a tissue level will be presented. A model of the action potential will be linked to the kinetics (attachment and detachment) of the proteins responsible for cardiac con traction (via the so called "crossbridges mechanism"). As a final step, the coupling of the calcium-dependent kinetics model to a higher-scale model of the left ventricle will complete the multi-scale model of cardiac dynamics from the sub cellular level to the organ.
机译:以统一而连贯的方式描述多尺度过程在心血管血管计算生理学中至关重要。在本文中,将提出一个将心脏兴奋和收缩过程从细胞水平转移到组织水平的模型。动作电位的模型将与负责心脏收缩的蛋白质的动力学(附着和脱离)联系起来(通过所谓的“跨桥机制”)。作为最后一步,将钙依赖性动力学模型耦合到左心室的高比例模型将完成从亚细胞水平到器官的心脏动力学的多比例模型。

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