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首页> 外文会议>International Conference on Medical Image Computing and Computer-Assisted Intervention(MICCAI 2007) pt.2; 20071029-1102; Brisbane(AU) >3-D Analysis of Cortical Morphometry in Differential Diagnosis of Parkinson's Plus Syndromes: Mapping Frontal Lobe Cortical Atrophy in Progressive Supranuclear Palsy Patients
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3-D Analysis of Cortical Morphometry in Differential Diagnosis of Parkinson's Plus Syndromes: Mapping Frontal Lobe Cortical Atrophy in Progressive Supranuclear Palsy Patients

机译：皮层形态计量学在帕金森氏综合症鉴别诊断中的3-D分析：进行性核上性麻痹患者额叶皮层萎缩的定位

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With the ability to study brain anatomy in vivo using magnetic resonance imaging, studies on regional brain atrophy suggest possible improvements for differential diagnosis of movement disorders with parkinsonian symptoms. In this study, we investigate effects of different parkinsonian syndromes on the cortical gray matter thickness and the geometric shape of the cerebral cortex. The study consists of a total of 24 patients with a diagnosis of probable progressive supranuclear palsy (PSP), multiple systems atrophy (MSA) or idiopathic Parkinson's disease (IPD). We examine dense estimates of cortical gray matter thickness, sulcal depth, and measures of the curvature in a surface-based cortical morphometry analysis framework. Group difference results indicate higher cortical atrophy rate in the frontal lobe in PSP patients when compared to either MSA or IPD. These findings are indicative of the potential use of routine MRI and cortical morphometry in performing differential diagnosis in PSP, MSA and IPD.
机译：借助使用磁共振成像技术在体内研究大脑解剖结构的能力，对区域性脑萎缩的研究表明，对于具有帕金森症状的运动障碍的鉴别诊断可能会有所改善。在这项研究中，我们调查了不同的帕金森氏综合征对皮质灰质厚度和大脑皮质的几何形状的影响。该研究共包括24位患者，诊断为可能进行性核上性麻痹（PSP），多系统萎缩（MSA）或特发性帕金森氏病（IPD）。我们在基于表面的皮层形态分析框架中检查了皮层灰质厚度，沟深和曲率测量的密集估计。群体差异结果表明，与MSA或IPD相比，PSP患者额叶的皮质萎缩率更高。这些发现表明在进行PSP，MSA和IPD的鉴别诊断时，常规MRI和皮质形态测量技术的潜在用途。

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