Polyrotaxanes: Challenge to Multivalent Binding with Biological Receptors on Cell Surfaces

机译：聚轮烷：挑战与细胞表面上的生物受体的多价结合。

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The challenge to multivalent binding between ligands and proteins or biological receptors on cell surfaces has been focused on using supramolecular-structured polymers, polyrotaxanes. Our designed polyrotaxanes consist of ligand-immobilized α-cyclodextrins (α-CDs) threaded onto a linear polymeric chain (polyethylene glydol) (PEG) capped both terminals with bulky end-groups via biodegradable linkages. Structural characteristics of these polyrotaxanes involve sliding and rotational motion of the ligands immobilized on α-CDs along a PEG chain as to easily face to binding sites on proteins, which can contribute much to enhanced multivalent binding with proteins.

机译：配体与蛋白质或细胞表面上的生物受体之间多价结合的挑战一直集中在使用超分子结构聚合物聚轮烷上。我们设计的聚轮烷由固定在线性聚合物链（聚乙二醇）（PEG）上的配体固定的α-环糊精（α-CD）组成，该链通过生物可降解的键合连接了两个末端带有庞大端基的末端。这些聚轮烷的结构特征涉及固定在α-CD上的配体沿着PEG链的滑动和旋转运动，从而易于面对蛋白质上的结合位点，这可以大大增强与蛋白质的多价结合。

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来源
《International Conference on Processing amp; Manufacturing of Advanced Materials Pt.4; Jul 7-11, 2003; Leganes, Madrid, Spain》|2003年|p.3243-3248|共6页
会议地点 Madrid(ES);Madrid(ES)
作者
Nobuhiko Yui; Tooru Ooya;
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作者单位

Japan Advanced Institute of Science and Technology 1-1, Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan;

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会议组织
原文格式 PDF
正文语种 eng
中图分类一般工业技术;
关键词
polyrotaxane; poly(ethylene glycol); α-cyclodextrin; multivalent interaction; ligand; receptor;

机译：聚轮烷;聚乙二醇;α-环糊精;多价相互作用;配体;受体;

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专利

1. Multivalent cations depress ligand affinity of insulin-like growth factor-binding proteins-3 and -5 on human GM-10 fibroblast cell surfaces (published erratum appears in J Cell Biochem 1998 Dec 1;71(3):459) [J] . Sackett RL, McCusker RH, McKusker-RH corrected to McCusker RH Journal of cellular biochemistry. . 1998,第3期

机译：多价阳离子抑制胰岛素样生长因子结合蛋白-3和-5对人GM-10成纤维细胞表面（公布的错误出现在J Cell Biochem 1998 Dec 1; 71（3）：459）
2. EQUILIBRIUM BINDING OF MULTIVALENT LIGANDS TO CELLS - EFFECTS OF CELL AND RECEPTOR DENSITY [J] . Sulzer B., Perelson AS. Mathematical Biosciences: An International Journal . 1996,第2期

机译：多价配体与细胞的平衡结合-细胞和受体密度的影响
3. Antigen-Specific Binding of Multivalent Soluble Antigen Arrays Induces Receptor Clustering and Impedes B Cell Receptor Mediated Signaling [J] . Hartwell Brittany L., Martinez-Becerra Francisco J., Chen Jun, Biomacromolecules . 2016,第3期

机译：多价可溶性抗原阵列的抗原特异性结合诱导受体簇集并阻碍B细胞受体介导的信号传导
4. Polyrotaxanes: Challenge to Multivalent Binding with Biological Receptors on Cell Surfaces [C] . Nobuhiko Yui, Tooru Ooya International Conference on Processing Manufacturing of Advanced Materials . 2003

机译：多岩烷：与细胞表面上与生物受体的多价结合的挑战
5. Analysis of epidermal growth factor binding to its cell surface receptor during short and long term quiescence in WI-38 cells [D] . Donigan, Anne Marie 1993

机译：WI-38细胞短期和长期静止期间表皮生长因子与其细胞表面受体结合的分析
6. Biological Effects of Polyrotaxane Surfaces on Cellular Responses of Fibroblast Preosteoblast and Preadipocyte Cell Lines [O] . Hiroki Masuda, Yoshinori Arisaka, Ruriko Sekiya-Aoyama, 2020

机译：聚轮烷表面对成纤维细胞成骨细胞和前脂肪细胞细胞系细胞应答的生物学效应
7. Steric effects on multivalent ligand-receptor binding: exclusion of ligand sites by bound cell surface receptors. [O] . Hlavacek, W S, Posner, R G, Perelson, A S 1999

机译：对多价配体-受体结合的立体效应：结合的细胞表面受体排除配体位点。

Polyrotaxanes: Challenge to Multivalent Binding with Biological Receptors on Cell Surfaces

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