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Inertia of Chemotactic Motion as an Emergent Property in a Model of an Eukaryotic Cell

机译:趋化运动的惯性作为真核细胞模型中的一个紧急属性。

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Chemotaxis is widely seen in many biological systems. Among them amoebic cells from unicellular slime molds to immune cells are believed to directly sense chemical gradients. Here, we construct a model of amoebic cell by taking account of the chemical kinetics as well as a cellular body. The model is composed of discrete grids and a set of rules which define chemical and motional events on each grid. The model can explain the observed features of the cellular locomotion. We find that the simulated cell tends to keep the direction of motion, which reminds us of "inertia" of motion in Newtonian dynamics. The averaged motion of amoebic cells approximately obeys an "underdamped" equation of motion for a short time scale. "Inertia" of chemotactic motion is an emergent property of the system where motion and the signal processing are strongly coupled to each other.
机译:趋化性在许多生物系统中广泛可见。从单细胞粘液霉菌到免疫细胞,其中的阿米巴细胞被认为直接检测化学梯度。在这里,我们通过考虑化学动力学以及细胞体来构建一个阿米巴细胞模型。该模型由离散的网格和一组定义每个网格上的化学和运动事件的规则组成。该模型可以解释观察到的细胞运动特征。我们发现,模拟单元倾向于保持运动方向,这使我们想起了牛顿动力学中运动的“惯性”。在短时间内,阿米巴细胞的平均运动近似服从“欠阻尼”运动方程。趋化运动的“惯性”是系统的新兴属性,其中运动和信号处理彼此紧密耦合。

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