• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) >Relationship between genetic susceptibility of non-small cell lung cancer and TGF-βRI gene
【24h】

Relationship between genetic susceptibility of non-small cell lung cancer and TGF-βRI gene

机译：非小细胞肺癌的遗传易感性与TGF-βRI基因的关系

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

investigate whether the transforming growth factor-beta receptor type I(TGF-βRI) gene is associated with genetic predisposition of primary non-small cell lung cancer (NSCLC). The entire coding region of TGF-βRI and flanking intron sequences from 53 NSCLC tissues were examined for alterations using SSCP and direct sequencing. No somatic point mutations other than two silent mutations and a polymorphism were found in the TGF-βRI gene. The two silent mutations located at codon 544 (AAT to AAC) and codon 406 (TTA to CTA), respectively, and the polymorphism was at 24 th base of intron7 (G to A). Interestingly, we found that the subjects with homozygous genotype A/A displayed more than threefold increased risk of developing NSCLC than the common wild genotype G/G. As the first report, this study showed that TGF-βRI gene is not a frequent site of spontaneous mutational inactivation while the detected polymorphism could be a susceptibility allele that predisposes to carcinogenesis of NSCLC.
机译：研究转化生长因子β受体I型（TGF-βRI）基因是否与原发性非小细胞肺癌（NSCLC）的遗传易感性相关。使用SSCP和直接测序检查了53个NSCLC组织的TGF-βRI的整个编码区和侧翼内含子序列的改变。在TGF-βRI基因中没有发现除了两个沉默突变和多态性以外的体细胞点突变。这两个沉默突变分别位于第544位密码子（从AAT到AAC）和第406位密码子（从TTA到CTA），并且多态性位于内含子7的24位碱基（从G到A）。有趣的是，我们发现具有纯合基因型A / A的受试者患NSCLC的风险比普通野生基因型G / G高出三倍以上。作为第一个报告，该研究表明，TGF-βRI基因不是自发突变失活的常见部位，而检测到的多态性可能是易感NSCLC致癌的易感性等位基因。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号