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首页> 外文会议>International symposium on integrative bioinformatics, 8th annual meeting >Predicting DNA Sequence Motifs of Recombination Hotspots by Integrative Visualization and Analysis
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Predicting DNA Sequence Motifs of Recombination Hotspots by Integrative Visualization and Analysis

机译：综合可视化与分析预测重组热点的DNA序列基序

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摘要

Meiotic recombination hotspots play important roles in life sciences, but the regulatory mechanism remain unclear. To predict DNA sequence motifs that regulate recombination hotspots, we designed an open source software tool called "LDsplit" that detects SNPs (single nucleotide polymorphisms) associated with meiotic recombination hotspots. The association is measured by the difference of historical recombination rates at a hotspot between two subpopulations with different alleles of a candidate SNP. Providing user-friendly graphic interface and integrative visualization, LDsplit provides insight into the relation of recombination hotspots with proximal DNA sequence patterns.
机译：减数分裂重组热点在生命科学中起着重要作用，但调控机制仍不清楚。为了预测调节重组热点的DNA序列基序，我们设计了一种称为“ LDsplit”的开源软件工具，用于检测与减数分裂重组热点相关的SNP（单核苷酸多态性）。通过候选SNP的不同等位基因的两个亚群之间的热点处的历史重组率的差异来测量关联。 LDsplit提供用户友好的图形界面和整合的可视化功能，可洞悉重组热点与近端DNA序列模式之间的关系。

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  • 来源
  • 会议地点 Hangzhou(CN)
  • 作者

    Peng Yang; Min Wu; Chee Keong Kwoh; Pavel P. Khil; R. Daniel Camerini-Otero; Teresa M. Przytycka; Jie Zheng;

  • 作者单位

    Bioinformatics Research Centre (BIRC), School of Computer Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798;

    Bioinformatics Research Centre (BIRC), School of Computer Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798;

    Bioinformatics Research Centre (BIRC), School of Computer Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798;

    NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA;

    NIDDK, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892, USA;

    NCBI, NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, Maryland 20894,USA;

    Bioinformatics Research Centre (BIRC), School of Computer Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物信息论;
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