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首页> 外文会议>International symposium on polymer physics : Preprints >DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF A NEW SERIES OF WATER SOLUBLE MOLECULAR WEIGHT GLUCAN STANDARDS
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DEVELOPMENT, CHARACTERIZATION AND EVALUATION OF A NEW SERIES OF WATER SOLUBLE MOLECULAR WEIGHT GLUCAN STANDARDS

机译：新型水溶性分子重量葡聚糖标准的开发，表征和评价

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@@Although high performance size exclusion chromatography (SEC) is usually equipped with laser light scattering (LLS) in academic labs for measurement of molecular weight (Mw) of polymers directly, SEC is yet frequently used in industries and some labs for determination of Mw and Mw distribution, for calibration and evaluation of instruments used in the quality control of synthesis/ processing, and comparing all kinds of measurement methods, because of its efficiency with aspects of time and cost. Since the retention volume in SEC depends on the hydrodynamic volume rather than Mw, the use of commercially available Mw standards such as pullulan and dextran can lead to a significant overestimation of some functional and medicinal polysaccharide having more expanded or rigid chain conformation in solution. This addresses needs to develop new Mw standard that is comparable to pullulan with regards to narrow Mw distribution but invariant chemical structure, thus, a more accurate Mw determination can be achieved. It has received much attention that biological property of polysaccharides appears to be largely dependent on accurate determination of Mw.
机译：@@尽管在学术实验室中高性能尺寸排阻色谱（SEC）通常配备有激光散射（LLS）来直接测量聚合物的分子量（Mw），但SEC在工业界和一些实验室中仍经常用于测定Mw和Mw分布，因为它在时间和成本方面具有效率，因此可以对用于合成/加工质量控制的仪器进行校准和评估，并比较各种测量方法。由于SEC中的保留体积取决于流体力学体积而不是Mw，因此使用市售Mw标准品（例如支链淀粉和葡聚糖）会导致对某些功能性和药用多糖的显着高估，这些多糖在溶液中具有更多的扩张或刚性链构象。这解决了开发新的Mw标准的需求，该标准在窄Mw分布但化学结构不变方面可与普鲁兰酶媲美，因此可以实现更准确的Mw测定。多糖的生物学特性似乎很大程度上取决于Mw的准确测定，已引起人们的广泛关注。

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