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首页> 外文会议>International Symposium on Supercritical Fluids Tome 1: Natural Products, Process amp; Equipment Development; 20030428-20030430; Versailles; FR >EXTRACTION AND ISOLATION OF INDOLE ALKALOIDS FROM Tabernaemontana catharinensis: TECHNICAL AND ECONOMICAL ANALYSIS
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EXTRACTION AND ISOLATION OF INDOLE ALKALOIDS FROM Tabernaemontana catharinensis: TECHNICAL AND ECONOMICAL ANALYSIS

机译：中华绒螯蟹中吲哚类生物碱的提取与分离：技术经济分析

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摘要

Leishmaniasis is a parasitic infection that is considered worldwide one of the most important public health problem, affecting more than 12 million people with an estimated number of 2 million new cases occurring annually. Among the compounds isolated from Tabernaemontana catharinensis, coronaridine and voacangine are the indole alkaloids which have antileishmanial activity. In this work, the technical and economical analysis of extraction and isolation of indole alkaloids from Tabernaemontana calharinensis is presented. The extraction was carried out using supercritical CO_2 as solvent and ethanol as cosolvent (9.2% m/m). The data were taken total solvent flow rate of 6.1 x 10~(-5) kg/s, pressures of 300 bar and temperature of 318.15 K. The extracts were fractionated and analyzed by Thin-layer chromatography and Gas-chromatography/Mass Spectrometry. The economical analysis was carried out considering that the cost of manufacturing can be obtained in terms of the costs of investment, operational labor, raw material, waste treatment and utilities.
机译：利什曼病是一种寄生虫感染，在世界范围内被认为是最重要的公共卫生问题之一，它影响了1200万人，估计每年有200万新病例发生。在从中华绒螯蟹分离的化合物中，coronaridine和voacangine是具有杀螨活性的吲哚生物碱。在这项工作中，技术和经济分析提供了从塔伯油菌（Tabernaemontana calharinensis）中提取和分离吲哚生物碱的技术分析。使用超临界CO 2作为溶剂和乙醇作为助溶剂（9.2％m / m）进行萃取。数据为总溶剂流速为6.1 x 10〜（-5）kg / s，压力为300 bar，温度为318.15K。提取液经分馏并通过薄层色谱法和气相色谱/质谱法进行分析。考虑到可以从投资成本，操作人工，原材料，废物处理和公用事业成本等方面获得制造成本，进行了经济分析。

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