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首页> 外文会议>IXth ESMB(European Society for Marine Biotechnology) Meeting May 12-14, 2002 Nantes >SQDGs from Porphyridium cruentum inhibit the proliferation of human cancer cell-lines
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SQDGs from Porphyridium cruentum inhibit the proliferation of human cancer cell-lines

机译：卟啉卟啉单胞菌的SQDGs抑制人癌细胞系的增殖

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Interest in the biological activity and pharmaceutical value of phyto-chemicals from marine origin has increased in the last decade. Many were found to possess in vitro selective toxicity against tumorigenic tissues and antiviral activity and therefore to possess a pharmaceutical potential. A crude SQDG sub-fraction isolated from the red microalga Porphyridium cruentum (SF) was found to inhibit in vitro the proliferation of murine immortalized L-929 cells and a panel of human solid cancer cells in a dose-dependant and cell-dependant manner via cytostatic and cyto-toxic effects. The strongest activity was observed on human colon carcinoma DLD-1 cells and the weakest on human breast carcinoma MCF-7 cells. Compared to SQDGs from spinach used as a standard of plant SQDGs, SQDGs from P. cruentum were found markedly more active on all tested cell-lines due, in part, to a stronger ability to inhibit mammalian DNA polymerase pol-α, a key enzyme for DNA replication. This latter property might be related to the presence of large amounts of arachi-donic and eicopentaenoic acid chains on the glycerol backbone. All these results suggested that SQDGs from Porphyridium cruentum might have a chemopreventive and/or chemotherapeutic potential. They justify new assays to isolate the most active compounds and evaluate their effectiveness in prevention and/or treatment of colon carcinoma.
机译：在过去的十年中，人们对来自海洋的植物化学物质的生物学活性和药用价值产生了兴趣。已发现许多药物具有针对致瘤组织的体外选择性毒性和抗病毒活性，因此具有一定的药物开发潜力。发现从红色微藻卟啉卟啉（SF）分离出的SQDG粗级分可通过剂量依赖性和细胞依赖性方式抑制鼠永生的L-929细胞和一组人类实体癌细胞的体外增殖。具有细胞生长抑制作用和细胞毒性作用。在人结肠癌DLD-1细胞上观察到最强的活性，而在人乳腺癌MCF-7细胞上观察到最弱的活性。与菠菜中的SQDGs用作植物SQDGs的标准品相比，P。cruentum的SQDGs在所有测试的细胞系中均具有明显更高的活性，部分原因是其抑制哺乳动物DNA聚合酶pol-α（一种关键酶）的能力更强。用于DNA复制。后一种性质可能与甘油主链上存在大量的花生四烯酸和二十碳四烯酸链有关。所有这些结果表明，来自卟啉卟啉菌的SQDG可能具有化学预防和/或化学治疗的潜力。他们证明了新的分析方法能够分离出活性最高的化合物并评估其在预防和/或治疗结肠癌中的有效性。

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