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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >A Population-Based Birth Cohort Study of the Association between Childhood-Onset Asthma and Exposure to Industrial Air Pollutant Emissions
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A Population-Based Birth Cohort Study of the Association between Childhood-Onset Asthma and Exposure to Industrial Air Pollutant Emissions

机译：基于人群的出生队列研究，研究了儿童哮喘发作与工业空气污染物排放之间的关系

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Background: Studies of the association between air pollution and asthma onset have mostly focused on urban and traffic-related air pollution. We investigated the associations between exposure to industrial emissions and childhood-onset asthma in a population-based birth cohort in Quebec, Canada, 2002-2011. Methods: The cohort was built from administrative health databases. We developed separately for PM2.5 and SO2 different metrics representing children's time-varying residential exposure to industrial emissions: 1) tons emitted yearly by all industries within 2.5 km; 2) distance to the nearest 'major emitter' (≥100 tons/year) within 7.5 km; 3) wind and inverse-distance weighted emissions of the nearest major emitter within 7.5 km. To handle the large number of zeros (i.e., children unexposed) we decomposed the exposure variable into two covariates simultaneously included in the regression model: A binary indicator of exposure and a continuous exposure variable centered at the mean value among exposed children. We performed Cox models using age as the time axis, adjusted for gender, material and social deprivation and calendar year. We indirectly adjusted for unmeasured secondhand smoke. Results: The cohort included 722,667 children and 66,559 incident cases of asthma. Across the different exposure metrics, mean percentage changes in the risk of asthma onset in children exposed to the mean relative to those unexposed ranged from 4.5% (95%CI: 2.8, 6.3%) to 10.6% (95%CI: 6.2, 15.2%) for PM2.5 and, from 1.1% (95%CI: -0.1, 3.3%) to 8.9% (95%CI: 7.1, 11.1%) for SO2. Indirect adjustment for secondhand smoke marginally influenced the associations. Among children exposed, the risk of asthma onset increased with the magnitude of the exposure for all metrics, except the distance to the nearest major emitter of SO2. Conclusion: In this population-based birth cohort, residential exposure to air pollutant emissions from industries was associated with childhood-onset asthma.
机译：背景：关于空气污染与哮喘发作之间关系的研究主要集中于城市和交通相关的空气污染。我们调查了2002-2011年加拿大魁北克市一个以人口为基础的出生队列中的工业排放暴露与儿童期哮喘的关系。方法：该队列来自行政健康数据库。我们针对PM2.5和SO2分别制定了不同的指标，这些指标代表儿童在时变的住宅中受到的工业排放量：1）2.5公里内所有行业每年排放的吨数； 2）距离最近的“主要排放源”（≥100吨/年）在7.5公里之内； 3）最近的主要排放源在7.5 km之内的风向和反距离加权排放。为了处理大量零（即未暴露的儿童），我们将暴露变量分解为同时包含在回归模型中的两个协变量：暴露的二元指标和以暴露的孩子的平均值为中心的连续暴露变量。我们使用年龄作为时间轴执行了Cox模型，并根据性别，物质和社会匮乏以及日历年度进行了调整。我们对未测得的二手烟进行了间接调整。结果：该队列包括722667名儿童和66559例哮喘病病例。在不同的暴露指标中，暴露于平均水平的儿童相对于未暴露水平的儿童的哮喘发作风险的平均百分比变化范围为4.5％（95％CI：2.8，6.3％）至10.6％（95％CI：6.2，15.2） PM2.5的百分比）和SO2的1.1％（95％CI：-0.1，3.3％）到8.9％（95％CI：7.1，11.1％）。二手烟的间接调整对这种关联影响很小。在所有暴露的儿童中，除与最近的主要SO2排放源之间的距离外，所有指标的哮喘发作风险均随暴露程度的增加而增加。结论：在这个以人口为基础的出生队列中，居民暴露于工业排放的空气污染物与儿童期哮喘有关。

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