首页> 外文会议>Journal of Huazhong Agricultural University ( Ziran Kexue Ban ) >Breeding for the High-yield Monacolin K Strains of Monascus sp. by the Mutagensis of UV LiCl
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Breeding for the High-yield Monacolin K Strains of Monascus sp. by the Mutagensis of UV LiCl

机译:红曲菌Monacolin K高产菌株的选育。通过UV和LiCl的Mutagensis

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摘要

In the 1970's, a Japanese scientist discovered that some strains of Monascus spp. when they grew on rice might produce a certain secondary metabolite, known collectively as Monacolin K, which could effectively inhibit HMG-CoA reduc-tase and had many bio-activities such as reducing the levels of TC (total cholesterol), TG (triglycer-ide), LDL (low density lipoprotein), and raising the level of HDL (high density lipoprotein), preventing the anti-AS (atherosclerotic) and so on, but the content in Monascus spp is extremely low, restricting the applications of red yeast rice and urging the researchers to seek for a lot of methods for enhancing the content of Monacolin K. In this paper, the mutagensis of UV and LiCl was applied to the strains of Monascus sp . for screening the high-yield Monacolin K strains.
机译:在1970年代,一位日本科学家发现了一些红曲菌菌株。当它们在水稻上生长时,可能会产生某种次级代谢产物,统称为Monacolin K,可以有效抑制HMG-CoA还原酶,并具有许多生物活性,例如降低TC(总胆固醇),TG(甘油三酯ide),LDL(低密度脂蛋白),提高HDL(高密度脂蛋白)水平,预防抗AS(动脉粥样硬化)等,但红曲菌中的含量极低,限制了红曲霉的应用水稻,并敦促研究人员寻找增加Monacolin K含量的许多方法。在本文中,将UV和LiCl的诱变剂应用于Monascus sp。菌株。用于筛选高产的莫纳可林K菌株。

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