Abstract: Formation of vapor bubbles is characteristic of manyapplications of short-pulse lasers in medicine. Anunderstanding of the dynamics of vapor bubblegeneration is useful for developing and optimizinglaser-based medical therapies. To this end, experimentsin vapor bubble generation with laser light depositedin an aqueous dye solution near a fiber-optic tip havebeen performed. Numerical hydrodynamic simulations havebeen developed to understand and extrapolate resultsfrom these experiments. Comparison of two-dimensionalsimulations with the experiment shows excellentagreement in tracking the bubble evolution. Anotherregime of vapor bubble generation is short-pulse laserinteractions with melanosomes. Strong shock generationand vapor bubble generation are common physicalfeatures of this interaction. A novel effect ofdiscrete absorption by melanin granules within amelanosome is studied as a possible role in previouslyreported high Mach number shocks $LB@Lin and Kelly,SPIE 2391, 294 (1995)$RB@. !22
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机译：摘要：气泡的形成是短脉冲激光在医学中的许多应用的特征。蒸气气泡生成动力学的理解对于开发和优化基于激光的医学疗法很有用。为此，已经进行了利用在光纤尖端附近的染料水溶液中沉积的激光产生蒸气气泡的实验。已经开发了数值流体动力学模拟来理解和推断这些实验的结果。二维模拟与实验的比较表明，在跟踪气泡演化方面达成了极好的协议。蒸气气泡产生的另一种方式是与黑素体的短脉冲激光相互作用。强烈的震动产生和蒸气气泡的产生是这种相互作用的共同物理特征。作为先前报道的高马赫数冲击$ LB @ Lin and Kelly，SPIE 2391，294（1995）$ RB @的可能作用，研究了釉质体内黑色素颗粒离散吸收的新作用。 ！22
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