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首页> 外文会议>Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII >Skin welding using pulsed laser radiation and a dye
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Skin welding using pulsed laser radiation and a dye

机译：使用脉冲激光辐射和染料进行皮肤焊接

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Abstract: Previous skin welding studies have used continuous wave (CW) delivery of radiation. However, heat diffusion during irradiation prevents strong welds from being achieved without creating large zones of thermal damage to surrounding tissue. This damage may prevent normal wound healing. Strong welds and minimal thermal damage can be achieved by introducing a dye and delivering the radiation in a pulsed mode. Two-cm-long, full-thickness incisions were made in guinea pig skin. India ink was used as an absorber, and egg white albumin was used as an adhesive. A 5-mm-diameter spot of CW, 1.06-micrometer Nd:YAG laser radiation was scanned over the weld site, producing 100 millisecond pulses. The cooling time between scans and number of scans was varied. Thermal damage zones were measured using a transmission polarizing microscope to identify birefringence changes in tissue. Tensile strengths were measured using a tensiometer. For pulsed welding and long cooling times, weld strengths of 2.4 kg/cm$+2$/ were measured, and thermal damage to the epidermis was limited to approximately 500 micrometers. With CW welding, comparable weld strengths resulted in approximately 2700 micrometer of thermal damage. CW laser radiation weld strengths were only 0.6 kg/cm$+2$/ when thermal damage in the epidermis was limited to approximately 500 micrometers. !15
机译：摘要：先前的皮肤焊接研究已使用连续波（CW）辐射。但是，辐射过程中的热扩散会阻碍牢固的焊接，而不会对周围组织产生较大的热损伤区域。这种损害可能会阻止正常的伤口愈合。通过引入染料并以脉冲模式传递辐射，可以实现牢固的焊接和最小的热损伤。在豚鼠皮肤上切成两厘米长的全层切口。印度墨水用作吸收剂，蛋白清蛋白用作粘合剂。在焊接位置上扫描了直径5毫米的连续光，1.06微米Nd：YAG激光辐射，产生了100毫秒的脉冲。扫描之间的冷却时间和扫描次数有所不同。使用透射偏振显微镜测量热损伤区域，以识别组织中的双折射变化。使用张力计测量拉伸强度。对于脉冲焊接和较长的冷却时间，测得的焊接强度为2.4 kg / cm $ + 2 $ /，并且对表皮的热损伤限制在大约500微米。使用连续波焊接，可比的焊接强度导致大约2700微米的热损伤。当表皮中的热损伤限制在大约500微米时，连续波激光辐射焊接强度仅为0.6 kg / cm $ + 2 $ /。 ！15

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