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Classical swine fever virus vaccine stability in Lao PDR

机译：老挝人民民主共和国的经典猪瘟病毒疫苗稳定性

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摘要

Classical swine fever (CSF) virus is a highly contagious but vaccine-preventable disease of swine. A locally produced lapinised C-strain vaccine is used to control CSF in Lao PDR; however, vaccine failure has been reported. The CSF vaccine is produced at the National Vaccine Production Centre (NVPC) as a freeze-dried rabbit spleen homogenate in a rubber stoppered glass vial and stored at -20 ℃ with a recommended shelf life of 1 year. This paper describes two studies to (ⅰ) determine the stability of the locally produced vaccine when stored at 4 ℃ and -20 ℃ and (ⅱ) determine if the vaccine elicits a protective immune response when delivered to village pigs under good transport conditions. The vaccine was found to be stable for only 4 months when stored at -20 ℃ and for less than 3 months when stored at 4 ℃. Under field conditions, vaccine stored at -20 ℃ for 2 months and transported at temperatures less than 1 ℃ elicited an immune response in 89% of vaccinated pigs by day 35 and 100% of pigs by day 70 post vaccination.
机译：古典猪瘟（CSF）病毒是一种具有高度传染性但可以通过疫苗预防的猪瘟。当地生产的Lapinized C株疫苗用于控制老挝人民民主共和国的脑脊液；然而，据报道疫苗失败。 CSF疫苗是由国家疫苗生产中心（NVPC）以冻干的兔脾匀浆形式在橡胶瓶塞玻璃瓶中生产的，并在-20℃下储存，建议保质期为1年。本文描述了两项研究，以（ⅰ）确定本地生产的疫苗在4℃和-20℃下存储时的稳定性，以及（ⅱ）确定疫苗在良好运输条件下运送到乡村猪时是否引发保护性免疫反应。发现该疫苗在-20℃下保存仅能稳定4个月，而在4℃下保存则可稳定3个月。在野外条件下，疫苗在-20℃下储存2个月并在低于1℃的温度下运输时，在接种后第35天时对89％的疫苗接种的猪产生了免疫反应，在接种后70天时对100％的猪引起了免疫反应。

著录项

  • 来源
  • 会议地点 Vientiane(LA)
  • 作者

    James Conlan; Tess Vitesnik; Syseng Khounsy; Colin Wilks; Laurence Gleeson;

  • 作者单位

    ACIAR Project AH/2003/001, National Animal Health Centre, Department of Livestock and Fisheries, Ministry of Agriculture and Forestry, Vientiane, Lao PDR CSIRO Livestock Industries, PO Bag 24, Geelong 3220, Victoria, Australia School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia;

    ACIAR Project AH/2003/001, National Animal Health Centre, Department of Livestock and Fisheries, Ministry of Agriculture and Forestry, Vientiane, Lao PDR School of Veterinary Science, The University of Melbourne, Parkville, Victoria, Australia;

    ACIAR Project AH/2003/001, National Animal Health Centre, Department of Livestock and Fisheries, Ministry of Agriculture and Forestry, Vientiane, Lao PDR;

    ACIAR Project AH/2003/001, National Animal Health Centre, Department of Livestock and;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
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