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首页> 外文会议>Materials science and technology VII >Preparation of 3DP Hydroxyapatite Composite By Single And Double Pass Poly(ε-caprolactone) Infiltration
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Preparation of 3DP Hydroxyapatite Composite By Single And Double Pass Poly(ε-caprolactone) Infiltration

机译：单双程聚（ε-己内酯）渗透法制备3DP羟基磷灰石复合材料

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Recently, porous hydroxyapatite was fabricated by three dimensional printing (3DP) in coupled with low temperature phosphorization to yield nanosized and low crystalline structure. However, brittleness was an intrinsic drawback for some foreseen applications. Polymer infiltration aiming to improve the toughness and mechanical integrity was thus carried out using biodegradable poly(e-caprolactone) (PCL) as an infiltrant since it has shown good biocompatibility together with a high elongation and energy to failure as compared to other medical polymers. Three routes of infiltration were performed including melt infiltration of low molecular weight PCL (Mw～10,000), solution infiltration by 10 % high molecular weight PCL (Mw ～ 80,000) and the combination of both melt and solution infiltration of low and high molecular weight PCL. The combination of low and high MW infiltration yielded the greatest increase in the mechanical properties and followed by the melt infiltration of low molecular weight PCL while the use of high MW infiltration yielded limited enhancement. After immersing in simulated body fluid (SBF), no significant changes in flexural properties were seen for both hydroxyapatite and high molecular weight infiltrated sample. However, flexural strength and strain at break of low molecular weight infiltrated sample largely dropped after 7 days of immersion to be closed to those of hydroxyapatite and high molecular weight infiltrated sample. The flexural properties of high-low infiltrated sample also decreased after immersion, but to a less degree and still maintained the greatest values amongst all samples. This could be associated to the difference in degradation of different molecular weight of PCL and the content of polymer infiltration induced by different infiltration routes. Calcium and phosphorus ions in the SBF were quantified and observed to be consumed continuously during immersion for all samples. Newly formed apatite crystals were observed to form on the surface of the infiltrated composites signifying that infiltration did not hinder the bioactivity of the composites.
机译：近来，通过三维印刷（3DP）结合低温磷化来制造多孔羟基磷灰石，以产生纳米尺寸和低结晶结构。但是，对于某些可预见的应用，脆性是其固有的缺点。因此，使用可生物降解的聚（ε-己内酯）（PCL）作为渗透剂进行了旨在提高韧性和机械完整性的聚合物渗透，因为与其他医用聚合物相比，它具有良好的生物相容性以及较高的伸长率和破坏能量。低分子量PCL（Mw〜10,000）的熔体渗透，10％高分子量PCL（Mw〜80,000）的溶液渗透以及低，高分子量PCL的熔体和溶液渗透的结合，共进行了三种渗透途径。 。低和高MW渗透的结合产生了机械性能的最大提高，随后是低分子量PCL的熔体渗透，而高MW渗透的使用产生了有限的增强。浸入模拟体液（SBF）后，羟基磷灰石和高分子量浸润样品的弯曲性能均未见明显变化。然而，低分子量浸润样品的抗弯强度和断裂应变在浸泡7天后大大降低，从而接近于羟基磷灰石和高分子量浸润样品的抗弯强度和断裂应变。浸入后，高低渗透样品的弯曲性能也有所下降，但程度较小，并且在所有样品中仍保持最大值。这可能与不同分子量PCL降解的差异以及不同渗透途径引起的聚合物渗透含量有关。对所有样品的SBF中的钙和磷离子进行定量，并观察到它们在浸入过程中被连续消耗。观察到新形成的磷灰石晶体在渗透的复合物表面上形成，这表明渗透不会阻碍复合物的生物活性。

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