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首页> 美国卫生研究院文献>Biomatter >Preparation of laminated poly(ε-caprolactone)-gelatin-hydroxyapatite nanocomposite scaffold bioengineered via compound techniques for bone substitution
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Preparation of laminated poly(ε-caprolactone)-gelatin-hydroxyapatite nanocomposite scaffold bioengineered via compound techniques for bone substitution

机译：通过复合骨替代技术生物工程制备层状聚（ε-己内酯）-明胶-羟基磷灰石纳米复合支架材料

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摘要

In this research, new bioactive nanocomposite scaffolds were successfully developed using poly(ε-caprolactone) (PCL), cross-linked gelatin and nanoparticles of hydroxyapatite (HAp) after testing different solvents and methods. First, HAp powder was synthesized via a chemical precipitation technique and characterized. Then, the nanocomposites were prepared through layer solvent casting combined with freeze-drying and lamination techniques. According to the results, the increasing of the PCL weight in the scaffolds led to the improvement of the mechanical properties. The amount of ultimate stress, stiffness and also elastic modulus increased from 8 MPa for 0% wt PCL to 23.5 MPa for 50% wt PCL. The biomineralization study revealed the formation of an apatite layer on the scaffolds after immersion in simulated body fluid (SBF). The Ca-P ratios were in accordance to nonstoichiometric biological apatite, which was approximately 1.67. The in vitro biocompatibility and cytocompatibility of the scaffolds were tested using mesenchymal stem cells (MSCs), and the results indicated no sign of toxicity, and cells were found to be attached to the scaffold walls. The in vivo biocompatibility and osteogenesis of these scaffolds in the animal experiments is also under investigation, and the result will be published at the end of the study.
机译：在这项研究中，通过测试不同的溶剂和方法，使用聚（ε-己内酯）（PCL），交联明胶和羟基磷灰石纳米颗粒（HAp）成功开发了新型生物活性纳米复合材料支架。首先，通过化学沉淀技术合成HAp粉末并进行表征。然后，通过层溶剂浇铸结合冷冻干燥和层压技术制备纳米复合材料。根据结果​​，支架中PCL重量的增加导致机械性能的改善。极限应力，刚度以及弹性模量从0％wt PCL的8 MPa增加到50％wt PCL的23.5 MPa。生物矿化研究表明，浸入模拟体液（SBF）后，支架上会形成磷灰石层。 Ca-P比率符合非化学计量的生物磷灰石，约为1.67。使用间充质干细胞（MSCs）测试了支架的体外生物相容性和细胞相容性，结果表明没有毒性迹象，并且发现细胞附着在支架壁上。这些支架在动物实验中的体内生物相容性和成骨性也正在研究中，其结果将在研究结束时公布。

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