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首页> 外文会议>Mechanisms for low-light therapy VI >The Effects of Photobiomodulation on Healing of Bone Defects in Streptozotocin Induced Diabetic Rats
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The Effects of Photobiomodulation on Healing of Bone Defects in Streptozotocin Induced Diabetic Rats

机译：光生物调节对链脲佐菌素诱导的糖尿病大鼠骨缺损愈合的影响

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Previous studies have shown positive effects of Low level laser therapy (LLLT) on the repair of bone defects, but there are only a few that associates bone healing in the presence of a metabolic disorder as Diabetes Melitus and LLLT. The aim of this study was to assess histologically the effect of LLLT (AsGaAl), 780nm, 70mW, CW, 0~O.4mm, 16J/cm2 per session) on the repair of surgical defects created in the femur of diabetic and non-diabetic Wistar Albinus rats. Surgical bone defects were created in 60 animals divided into four groups of 15 animals each: Group C (non-diabetic - control); Group CL (non-diabetic + LLLT); Group CD (diabetic); Group CDL (diabetic + LLLT). The animals on the irradiated group received 16 J/cm2 per session divided into four points around the defect, being the first irradiation immediately after surgery and repeated every 48h for 14 days. The animals were killed 15, 21 and 30 days after surgery. The results of the present investigation showed histological evidence of improved amount of collagen fibers at early stages of the bone healing (15 days) and increased amount of well organized bone trabeculae at the end of the experimental period (30 days) on irradiated animals, (diabetic and non-diabetic) compared to non irradiated ones. It is concluded that LLLT has a positive biomodulative effect on the healing process of bone defects, even when diabetes mellitus was present.
机译：先前的研究表明，低水平激光疗法（LLLT）对修复骨缺损具有积极作用，但是在代谢紊乱的情况下，如糖尿病糖尿病和LLLT，只有少数几种与骨骼愈合有关。这项研究的目的是从组织学上评估LLLT（AsGaAl），780nm，70mW，CW，0〜O.4mm，16J / cm2每节）对糖尿病性和非糖尿病性股骨产生的手术缺损的修复作用。糖尿病Wistar Albinus大鼠。在60只动物中创建了手术骨缺损，将其分为四组，每组15只动物：C组（非糖尿病-对照组）； C组（非糖尿病-对照）； C组（非糖尿病-对照组）。 CL组（非糖尿病+ LLLT）； CD组（糖尿病）；组CDL（糖尿病+ LLLT）。辐照组的动物每次疗程接受16 J / cm2，分为缺陷周围的四个点，这是手术后立即进行的第一次辐照，每48h重复一次，持续14天。手术后15、21和30天将动物处死。本研究的结果表明，组织学证据表明，受辐照的动物在骨愈合的早期阶段（15天）胶原纤维数量增加，在实验期（30天）结束时组织良好的骨小梁数量增加，（糖尿病和非糖尿病患者）。结论是，即使存在糖尿病，LLLT对骨缺损的愈合过程也具有积极的生物调节作用。

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