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首页> 外文会议>Mechanisms for Low-Light Therapy; Progress in Biomedical Optics and Imaging; vol.7 no.26 >Activation of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) induced angiogenesis under influence of low level laser radiation in vitro
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Activation of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) induced angiogenesis under influence of low level laser radiation in vitro

机译：体外低水平激光照射下血管内皮生长因子（VEGF）和成纤维细胞生长因子（FGF）的激活诱导血管生成

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One of the feasible explanations for long-term treatment effects of laser therapy of diseases connected with tissue ischemia and altered blood circulation is activation of angiogenesis after low level laser irradiation. The aim of the current study was to investigate if laser irradiation can enhance vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (FGF) induced angiogenesis in vitro. The study was conducted on rat thoracic aortal rings. Samples of group 1 served as control, samples of groups 2 and 3 were incubated with VEGF or FGF, group 4 samples were irradiated with laser (660 run, 20 mW) during 10 min, samples of groups 5 and 6 were incubated with VEGF or FGF accordingly and received 10 min of laser irradiation. In the control group no noticeable angiogenesis occurred. The application of VEGF activated angiogenesis: the area covered by new vessels was 1,3±0,24 mm~2 and the maximal length of vessels was 0,93±0,11 mm. Laser light irradiation (group 4) activated angiogenesis (1,9±0,29 mm~2 and 0,75±0,10 mm). The combined influence of laser light and VEGF on angiogenesis (group 5) was significantly stronger (p < 0,001), than each of the factors separately (6,98±0,88 mm~2 and 1,7±0,23 mm). Application of FGF also activated angiogenesis: the area covered by new vessels was 2,76±0,22 mm~2 and the maximal length of vessels was 1,19±0,12 mm. Combined influence of laser light and FGF on angiogenesis (group 6) was again significantly stronger (p < 0,001), than each of the factors separately (5,43±0,28 mm~2 and 1,99±0,10 mm). Studies show that laser irradiation can intensify effects of growth factors in vitro.
机译：对与组织缺血和血液循环改变有关的疾病进行激光治疗的长期治疗效果的可行解释之一是低水平激光照射后血管生成的激活。当前研究的目的是研究激光照射是否可以增强血管内皮生长因子（VEGF）或碱性成纤维细胞生长因子（FGF）体外诱导的血管生成。该研究是在大鼠胸主动脉环上进行的。第一组的样品作为对照，第2和第3组的样品与VEGF或FGF孵育，第4组的样品在10分钟内用激光（660 run，20 mW）照射，第5和第6组的样品与VEGF或FGF孵育。因此，FGF并接受了10分钟的激光照射。在对照组中没有发生明显的血管生成。 VEGF激活血管生成的应用：新血管覆盖面积为1.3±0.24mm〜2，最大血管长度为0.93±0.11mm。激光照射（第4组）激活血管生成（1.9±0.29 mm〜2和0.75±0.10 mm）。激光和VEGF对血管生成的综合影响（第5组）明显强于（p <0,001），分别高于各个因素（6,98±0,88 mm〜2和1,7±0.23 mm） 。 FGF的应用还激活了血管生成：新血管覆盖的面积为2.76±0.22mm〜2，最大血管长度为1.19±0.12mm。激光和FGF对血管生成的综合影响（第6组）再次显着更强（p <0,001），分别高于各个因素（5,43±0.28 mm〜2和1,99±0.10 mm） 。研究表明，激光照射可增强体外生长因子的作用。

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