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Regional wall motion analysis: an important tool to study pharmacologic agents in the absence of systemic effects

机译：区域壁运动分析：在没有全身作用的情况下研究药理作用的重要工具

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The authors present a method of quantitative regional wall motion analysis able to provide a precise evaluation of the effects of an intracoronary infused drug on the systolic and diastolic myocardial function in patients with aortic stenosis. The computation of the changes in regional areas, of regional peak filling rate, of an index of regional chamber stiffness and of the changes in regional area during isovolumic relaxation revealed a selective improvement of myocardial diastolic function in the perfused territory. As this improvement remained undetected when the global indices of left ventricular function were examined, it is concluded that regional wall motion analysis is indispensable to correctly assess the effects of intracoronary drug administration.

机译：作者提出了一种定量区域壁运动分析的方法，该方法能够对主动脉狭窄患者冠状动脉内注射药物对收缩和舒张心肌功能的影响进行精确评估。在等容松弛期间，对区域面积的变化，区域峰值填充率，区域腔室刚度的指数以及区域面积的变化的计算表明，灌注区域的心肌舒张功能有选择性的改善。由于在检查左心室功能的整体指标时仍未发现这种改善，因此得出结论，区域壁运动分析对于正确评估冠状动脉内给药的效果必不可少。

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《》|1992年|P.527-530|共4页
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van Eyll; C.; Stoleru; L.;
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中图分类无线电电子学、电信技术;
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Regional wall motion analysis: an important tool to study pharmacologic agents in the absence of systemic effects

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