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A field potential analysis study of the effects of prenatal protein malnutrition on maturation of the dentate granule cell response

机译:产前蛋白质营养不良对齿状颗粒细胞反应成熟的影响的田间潜力分析研究

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Unlike the vast majority of cells making up the rat central nervous system, the granule cell population of the hippocampal dentate gyrus develops primarily after birth. Only about 20% of these cells are in place at the time of birth, with the remaining 80% reaching functional maturity by around 30 days of postnatal development. This relatively unique developmental pattern provides an opportunity to assess the impact of insults encountered during the gestational period on the subsequent development and maturation of a brain structure intimately involved in such fundamental processes as spatial navigation, learning, and memory. In addition, the morphology of the hippocampal dentate gyrus, with its laminated arrangement of densely packed cell bodies and specifically oriented apical and basilar projections, provides a structure well-suited to electrophysiological characterization employing field potential analysis. The present study was undertaken to examine the impact of prenatal protein malnutrition on the development of neuronal transmission across the perforant path-dentate granule cell synapse of the hippocampal formation in freely moving rats as they matured from 15 to 30 days of age.
机译:与组成大鼠中枢神经系统的绝大多数细胞不同,海马齿状回的颗粒细胞群主要在出生后发育。这些细胞仅约20%在出生时就位,其余80%在出生后30天左右达到功能成熟。这种相对独特的发育模式提供了一个机会,可以评估妊娠期受到的侮辱对与空间导航,学习和记忆等基本过程密切相关的大脑结构的后续发育和成熟的影响。此外,海马齿状回的形态,其密集排列的细胞体的层叠排列以及特定方向的顶端和基底突起,提供了一种非常适合利用场电势分析进行电生理学表征的结构。进行本研究是为了研究产前蛋白质营养不良对15至30天成龄的自由移动大鼠横穿海马形成的穿孔路径-齿状颗粒细胞突触的神经元传递的发展的影响。

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