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A method for fabricating collagen membranes with microporous structure: applications in tissue engineering

机译:一种具有微孔结构的胶原膜的制备方法:在组织工程中的应用

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The goal of this project was to create membranes with a microporous architecture capable of supporting layers of cultured cells while preserving the molecular structure and mechanical integrity of the collagen. In this study, we investigated several methods for fabricating porous membranes and showed that porous collagen membranes could be formed using a combination of fibril formation, controlled drying, and freeze-drying. Scanning electron microscopy (SEM) analyses of these collagen membranes indicate that a microporous architecture was created by modulating the processing of the membrane. Ultimately, the ability to regulate porosity will lead to improved control in the overall performance of a tissue engineered construct.
机译:该项目的目的是创建一种具有微孔结构的膜,该膜能够支持培养细胞的各层,同时保留胶原蛋白的分子结构和机械完整性。在这项研究中,我们研究了几种制造多孔膜的方法,结果表明,可以结合使用原纤维形成,控制干燥和冷冻干燥来形成多孔胶原膜。这些胶原膜的扫描电子显微镜(SEM)分析表明,通过调节膜的加工过程可形成微孔结构。最终,调节孔隙率的能力将导致对组织工程构造体的总体性能进行更好的控制。

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