首页> 外国专利> RUBBERY, COMPLIANT, AND SUTURABLE COLLAGEN-BASED SCAFFOLDS FOR TISSUE ENGINEERING APPLICATIONS

RUBBERY, COMPLIANT, AND SUTURABLE COLLAGEN-BASED SCAFFOLDS FOR TISSUE ENGINEERING APPLICATIONS

机译:面向组织工程应用的基于橡胶的,可兼容的和可固化的基于胶原的支架

摘要

A collagen-based or gelatin-based formulation that is compliant yet strong and has a high suture-strength value is disclosed. This material is simple to synthesize, behaves like a rubbery material, and is the first type of solely collagen-based compliant material without using elastin. The formulation maintains the strength of collagen, but can be stretched to several times its initial dimension and can be sutured without leaking. The suture retention strength can reach up to 350-grams force. The presently disclosed collagen-based formulation can be used in variety of applications where high strength, compliance, or stretchability is required, such as in urinary tissues, intestinal tissues, heart tissues, and skin.
机译:公开了一种顺应性但强并且具有高缝合强度值的基于胶原或基于明胶的制剂。这种材料易于合成,表现得像橡胶般的材料,并且是第一类完全不使用弹性蛋白的完全基于胶原蛋白的材料。该制剂可保持胶原蛋白的强度,但可以拉伸至其初始尺寸的几倍,并且可以缝合而不会泄漏。缝线保持强度可以达到350克力。当前公开的基于胶原的制剂可用于需要高强度,顺应性或可拉伸性的各种应用中,例如在泌尿组织,肠组织,心脏组织和皮肤中。

著录项

  • 公开/公告号WO2020041407A1

    专利类型

  • 公开/公告日2020-02-27

    原文格式PDF

  • 申请/专利权人 THE JOHNS HOPKINS UNIVERSITY;

    申请/专利号WO2019US47405

  • 发明设计人 SINGH ANIRUDHA;

    申请日2019-08-21

  • 分类号C08L89;C07K14/78;C09H9;A61L27/22;A61L27/24;

  • 国家 WO

  • 入库时间 2022-08-21 11:13:14

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