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In vivo imaging of blood-spinal cord barrier permeability with dynamic contrast enhanced MRI of spinal cord injury

机译：动态对比增强对脊髓损伤的MRI显示的血脊髓屏障通透性的体内成像

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Serial in vivo dynamic contrast enhanced MRI studies were performed on spinal cord injured rats on post-injury days 0, 10, 20 and 30 to determine the distribution of gadopentetate-dimeglumine (Gd) concentration in injured cord tissue. A two-compartment pharmacokinetic model was fitted to describe the time course of the concentration data at the epicenter of injury for each post-injury day. From these fits, the rates of Gd transport between plasma and injured cord tissue were determined to estimate the blood-spinal cord barrier permeability. The results indicated a steady decrease in the Gd transport rates with a concomitant improvement in rat's motor functions with post-injury time. Specifically, the rates of Gd accumulation in injured cord and its clearance correlated with the neurobehavioral scores strongly, suggesting a causal relation between the neurobehavioral function and the restoration of barrier integrity as a result of the ongoing repair and recovery processes within the injured cords.
机译：在受伤后第0、10、20和30天，对脊髓损伤的大鼠进行了一系列体内动态对比增强MRI研究，以确定在受损的脊髓组织中g戊二酸二聚丁二胺（Gd）浓度的分布。拟合了两室药代动力学模型，以描述每个损伤日在受伤震中的浓度数据的时间过程。从这些拟合中，确定血浆与受损脐带组织之间的Gd转运速率，以估计血脊髓屏障的通透性。结果表明，Gd转运速率稳定下降，大鼠运动功能随损伤时间的延长而改善。具体而言，受伤的脐带中Gd积累的速率及其清除率与神经行为评分密切相关，这表明由于受伤的脐带内正在进行的修复和恢复过程，神经行为功能与屏障完整性的恢复之间存在因果关系。

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