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Molecular mechanism of coix seed with anti-diabetes activity based on network pharmacology

机译：基于网络药理学的抗糖尿病活性薏ix仁的分子机制

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The molecular mechanism of coix seed used to treat diabetes was studied based on network pharmacology. The active components of coix seed were obtained by TCMSP database. The target of coix seed active compounds was screened by HIT and TTD database, then target dataset was established, OMIM database was used to screen diabetes-related targets, and PPI database was used to construct interactive targets of coix seed and diabetes. The "component-target-disease" interaction network was constructed using Cytoscape software and the target gene function and signal pathways were analyzed by ClueGO plug-in. 29 active constituents of Coix seed were obtained. The network analysis indicated that the active components of Coix seed are closely related to the 35 protein targets such as Cellular tumor antigen p53, Estrogen receptor, Nitric oxide synthase, endothelial, etc. In addition, Insulin resistance, Insulin signaling pathway, Type II diabetes mellitus, and apoptosis signal pathways were involved. This study provides new ideas and new directions for further research on the anti-diabetic mechanism of Coix seed.
机译：基于网络药理学研究了用于治疗糖尿病的薏ix子的分子机制。通过TCMSP数据库获得COIX种子的活性组分。通过HIT和TTD数据库筛选COIX种子活性化合物的靶标，然后建立靶数据集，OMIM数据库用于筛选糖尿病相关的靶标，并且PPI数据库用于构建COIX种子和糖尿病的互动靶标。使用Cytoscape软件构建“组分 - 靶疾病”相互作用网络，并通过ClueGo插入分析靶基因函数和信号途径。 29获得薏ix仁的活性成分。网络分析表明，薏ix仁的活性成分与35蛋白靶标如细胞肿瘤抗原P53，雌激素受体，一氧化氮合酶，内皮等密切相关。此外，胰岛素抵抗，胰岛素信号通路，II型糖尿病涉及MELLITUS和凋亡信号途径。本研究为进一步研究薏ix仁抗糖尿病机制的进一步研究提供了新的思路和新方向。

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