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Microwave-induced thermoacoustic tomography for whole-body neonatal mouse imaging

机译：微波诱导的全身新生鼠鼠标成像热声学断层扫描

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Mouse is an ideal animal model for phenotyping. However, current methods available for in-vivo whole-body imaging of mouse embryos and newborns lack the ability to provide electrical properties of internal tissue with high temporal resolution. Microwave-induced thermoacoustic tomography (TAT) combines deep penetration depth of microwave with high resolution of ultrasonic imaging, which is a novel non-invasive imaging modality for mapping the electrical properties of tissue. In this study, for the first time, a cylindrical-scanning TAT system was developed with optimized microwave irradiation and ultrasound detection for whole-body neonatal mouse imaging. And its potential in visualizing the internal organs and structures of neonatal mice was evaluated by comparing with corresponding frozen histological photographs. The results demonstrated that TAT can noninvasively visualize the boundary and internal structures of newborns mice based on electrical properties of tissue, which could provide complementary information to magnetic resonance imaging (MRI) as it delivers a novel tissue contrast, which is very different from other modalities.
机译：鼠标是表型的理想动物模型。然而，目前可用于小鼠胚胎和新生儿的体内全身成像的方法缺乏能够提供具有高时间分辨率的内部组织的电性能。微波诱导的热声学断层扫描（TAT）将微波深度与超声波成像的高分辨率相结合，这是一种用于映射组织的电特性的新型非侵入性成像模型。在本研究中，首次开发了圆柱形扫描TAT系统，用于全身新生小鼠成像的优化微波辐射和超声检测。通过与相应的冷冻组织学照片进行比较，评估其在可视化内部器官和新生小鼠的结构方面的潜力。结果表明，基于组织的电特性，TAT可以非侵入地可视化新生儿小鼠的边界和内部结构，这可以为磁共振成像（MRI）提供互补信息，因为它提供了与其他方式截然不同的新型组织对比。

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