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A High Sensitivity Multi-Spectral Three-Dimensional Fluorescence Optical Tomography System for Small Animal Imaging

机译：用于小动物成像的高灵敏度多光谱三维荧光光学层析成像系统

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摘要

We have designed a three dimensional (3D) fluorescence optical tomography system for small animal imaging based on an innovative system geometry that uses a truncated conical mirror which permits the entire surface of the animal to be viewed simultaneously by a single CCD camera. Compared with traditional approaches that employ a flat mirror, the conical mirror system has approximately 3 times better measurement sensitivity. By utilizing a fast switching filter wheel (switching time < 100 milliseconds), emission data at multiple wavelengths can be efficiently collected. An array of appropriately shaped neutral density filters, mounted on a linear stage, can be used to increase the system measurement dynamic range by 3 orders of magnitude. An x-y galvo mirror scanning system makes it possible to scan a collimated laser beam to any location on the mouse surface. A pattern of structured light incident on the animal surface is used to extract the surface geometry. A finite element based algorithm is applied to model photon propagation in the turbid media and a preconditioned conjugate gradient (PCG) method is used to solve the large linear system matrix. The reconstruction algorithm and the system performance are evaluated by phantom experiments.
机译：我们基于一种创新的系统几何结构设计了一种用于小动物成像的三维（3D）荧光光学层析成像系统，该系统采用了截头圆锥形镜，可通过单个CCD相机同时观察动物的整个表面。与采用平面镜的传统方法相比，锥形镜系统的测量灵敏度提高了约3倍。通过使用快速切换滤光轮（切换时间<100毫秒），可以有效收集多个波长的发射数据。安装在线性平台上的适当形状的中性密度滤光片阵列可用于将系统测量动态范围增加3个数量级。 x-y振镜扫描系统可以将准直的激光束扫描到鼠标表面上的任何位置。入射到动物表面的结构化光的图案用于提取表面几何形状。将基于有限元的算法应用于光子在混浊介质中的传播模型，并使用预处理共轭梯度（PCG）方法求解大型线性系统矩阵。通过幻象实验评估了重建算法和系统性能。

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  • 来源
    《》|2009年|717415.1-717415.8|共8页
  • 会议地点 San Jose CA(US)
  • 作者

    Changqing Li; Gregory S. Mitchell; Joyita Dutta; Sangtae Ahn; Richard M. Leahy; Simon R. Cherry;

  • 作者单位

    Department of Biomedical Engineering, UC Davis, Davis, CA 95616;

    Department of Biomedical Engineering, UC Davis, Davis, CA 95616;

    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089;

    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089;

    Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089;

    Department of Biomedical Engineering, UC Davis, Davis, CA 95616;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    fluorescence optical tomography; small animal imaging; conical mirror;

    机译：荧光光学层析成像小动物成像；锥形镜;

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