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Multiplex PCR CMOS Biochip for Detection of Upper Respiratory Pathogens including SARS-CoV-2

机译:用于检测上呼吸道病原体的多重PCR CMOS Biochip,包括SARS-COV-2

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A 1024-pixel CMOS biochip for multiplex polymerase chain reaction application is presented. Biosensing pixels include 137dB DDR photosensors and an integrated emission filter with OD~6 to perform real-time fluorescence-based measurements while thermocycling the reaction chamber with heating and cooling rates of > ±10°C/s. The surface of the CMOS IC is biofunctionalized with DNA capturing probes. The biochip is integrated into a fluidic consumable enabling loading of extracted nucleic acid samples and the detection of upper respiratory pathogens, including SARS-CoV-2.
机译:提出了用于多路复用聚合酶链反应应用的1024像素CMOS Biochip。 生物强直像素包括137dB DDR光电传感器和具有OD〜6的集成发射滤波器,以进行实时荧光的测量,同时将反应室热循环加热和冷却速率>±10°C / s的冷却速度。 CMOS IC的表面与DNA捕获探针生物官能化。 将生物芯片集成到流体耗材中,使能量的核酸样品和上呼吸道病原体的检测,包括SARS-COV-2。

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